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      Benign thyroid disease and the risk of breast cancer: An updated systematic review and meta-analysis

      systematic-review

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          Abstract

          Background

          The correlation between benign thyroid disease (BTD) and breast cancer (BC) has long been discussed. However, the definite relationship and potential mechanism between them are still disputed. The current meta-analysis aimed at performing a comprehensive assessment of the relationship between different types of benign thyroid disease and the risk of breast cancer, furthermore, assessing whether benign thyroid disease exerts an influence on the aggressiveness of breast cancer.

          Method

          A systematic literature search (PubMed, Web of Science, MEDLINE, and Embase databases) identified studies to evaluate the correlation between BTD and BC risk. Data were analyzed using version 16.0 STATA software, including the odds ratio (OR) and its corresponding 95% confidence intervals (CIs). Publication bias and quality assessment were conducted for the included studies.

          Result

          Overall, 18 studies involving 422,384 patients with BTD were incorporated. The outcome showed that autoimmune thyroiditis (OR: 2.56, 95%CI: 1.95–3.37, I 2 = 0.0%, p=0.460), goiter (OR: 2.13, 95%CI: 1.19-3.79, I 2 = 80.6%, p=0.000), and Graves’ disease (OR: 5.01, 95%CI: 1.49-16.82, I 2 = 0.0%, p=0.358) was connected with a higher risk of BC. Both hypothyroidism (OR: 0.82, 95%CI: 0.64-1.04, I 2 = 85.0%, p=0.000) and hyperthyroidism (OR: 1.07, 95%CI: 0.93-1.24, I 2 = 24.9%, p=0.206) had no significant association with the risk of BC. Additionally, the pooled analysis showed no apparent correlation between BTD and aggressiveness of BC. However, subgroup analysis indicated a positive relationship between BTD and aggressiveness of BC in the Europe subgroup (HR: 2.05, 95%CI: 1.32-3.17, I 2 = 86.4%, p=0.000).

          Conclusion

          Autoimmune thyroiditis, goiter, and Graves’ disease are connected with an increased risk of BC. Furthermore, subgroup analysis suggested that BTD increases the aggressiveness of BC in the European population geographically. Nevertheless, further research is needed to prove these discoveries.

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          Measuring inconsistency in meta-analyses.

          Julian P. T. Higgins, Simon Thompson, Jonathan Deeks … (2003)
          Article 0 comments Cited 10324 times – based on 0 reviews     Review now
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            Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

            David Moher, Larissa Shamseer, Mike Clarke … (2017)
            Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium.
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              Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.

              Andreas Stang (2010)
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                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Endocrinol (Lausanne)
                Journal ID (iso-abbrev): Front Endocrinol (Lausanne)
                Journal ID (publisher-id): Front. Endocrinol.
                Title: Frontiers in Endocrinology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1664-2392
                Publication date (Electronic): 12 October 2022
                Publication date Collection: 2022
                Volume: 13
                Electronic Location Identifier: 984593
                Affiliations
                [1] 1 Department of Endocrinology and Metabolism, The First Hospital of Jilin University , Changchun, China
                [2] 2 Department of Orthopedics, The Second Hospital Jilin University , Changchun, China
                [3] 3 Hospital Office, Meihekou City Central Hospital , Meihekou, China
                Author notes

                Edited by: Maria Celeste Diaz Flaqué, Institute for Biomedical Research (BIOMED) (CONICET), Argentina

                Reviewed by: Eusebio Chiefari, University Magna Graecia of Catanzaro, Italy; Xiadi He, Dana–Farber Cancer Institute, United States

                *Correspondence: Guixia Wang, gwang168@ 123456jlu.edu.cn ; Xiaokun Gang, ganggangxk@ 123456jlu.edu.cn

                †These authors share first authorship

                This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology

                Article
                DOI: 10.3389/fendo.2022.984593
                PMC ID: 9596990
                PubMed ID: 36313770
                SO-VID: c24bb484-d12d-4a0a-87cd-a68140c013c1
                Copyright © Copyright © 2022 Han, Wang, Jin, Zhao, Cui, Wang and Gang
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 02 July 2022
                Date accepted : 26 September 2022
                Page count
                Figures: 5, Tables: 1, Equations: 0, References: 53, Pages: 11, Words: 4528
                Categories
                Subject: Endocrinology
                Subject: Systematic Review

                ScienceOpen disciplines: Endocrinology & Diabetes
                Keywords: benign thyroid disease,breast cancer,aggressiveness,meta-analysis,female
                Data availability:
                ScienceOpen disciplines: Endocrinology & Diabetes
                Keywords: benign thyroid disease, breast cancer, aggressiveness, meta-analysis, female

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