Anti-osteoporotic effects of Salvia miltiorrhiza Bunge EtOH extract both in ovariectomized and naturally menopausal mouse models.

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Abstract

Salvia miltiorrhiza is a traditional oriental medicine widely used for preventing and treating disorders of the liver, menstrual, and blood circulation systems. Osteoporosis, loss of bone with age and/or estrogen deficiency, is an important causal factor of fracture. S. miltiorrhiza extract has been used to alleviate dysmenorrhea and painful osteoarthritis.

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Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Aug 10 2020

Volume: 258

Affiliations

[1 ] Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan, 47392, Republic of Korea. Electronic address: lsr1113@inje.ac.kr.

[2 ] Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address: jeonhl0219@genencell.co.kr.

[3 ] Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address: jjung@nmr.kr.

[4 ] Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address: suhhj0208@nmr.kr.

[5 ] UNDBIO Co., Ltd, Suwon, 16229, Republic of Korea. Electronic address: protein0826@snu.ac.kr.

[6 ] R&D Center, SK Bioland Co, Ltd, Ansan, 5407, Republic of Korea. Electronic address: minkyu88@sk.com.

[7 ] Cosmax Bio R&D Center, Cosmax Bio Inc., Seongnam, 13486, Republic of Korea. Electronic address: yjlim@cosmax.com.

[8 ] Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address: sckang@khu.ac.kr.

Article

Publisher Item ID: S0378-8741(19)33969-8

DOI: 10.1016/j.jep.2020.112874

PubMed ID: 32311485

SO-VID: c23564e5-1a34-4e91-904a-97ceb8e52b6a

History

Keywords: Bone mineral density,Bone resportipon,Salvia miltiorrhiza,Menopause,Osteoporosis,Osteoclast differentiation

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Keywords: Bone mineral density, Bone resportipon, Salvia miltiorrhiza, Menopause, Osteoporosis, Osteoclast differentiation

Anti-osteoporotic effects of Salvia miltiorrhiza Bunge EtOH extract both in ovariectomized and naturally menopausal mouse models.

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