Steroids in porifera. II. Steroid derivatives from two sponges of the family Halichondriidae. Sokotrasterol sulfate,a marine steroid with a new pattern of side chain alkylation
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
A trisulfated derivative of 24,25,26,26-tetramethyl-5 alpha-cholest-23E-ene-2 alpha,
3 beta, 6 alpha-triol (sokotrasterol sulfate) has been isolated from the sponge Halichondriidae
gen. sp., collected near Sokotra Island (Arabian Sea), and its structure has been
elucidated. The side chain of the new steroid involves a "normal" alkylation at C-24
and the unprecedented addition of two extra methyl groups at C-26 and one extra methyl
group at C-25. A free sterol fraction contained only 24-isopropyl-5-cholesten-3 beta-ol
and 24-isopropyl-5, 22E-cholestadien-3 beta-ol. 24-Isopropyl-5, 22E-cholestadien-3
beta-ol as sole monohydroxy sterol and halistanol sulfate as major polyhydroxylated
steroid derivative have been detected in Halichondria sp., a Madagascar sponge.