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      Allograft loss from acute Page kidney secondary to trauma after kidney transplantation

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          Abstract

          We report a rare case of allograft loss from acute Page kidney secondary to trauma that occurred 12 years after kidney transplantation. A 67-year-old Caucasian male with a past surgical history of kidney transplant presented to the emergency department at a local hospital with left lower abdominal tenderness. He recalled that his cat, which weighs 15 lbs, jumped on his abdomen 7 d prior. On physical examination, a small tender mass was noticed at the incisional site of the kidney transplant. He was producing a normal amount of urine without hematuria. His serum creatinine level was slightly elevated from his baseline. Computer tomography revealed a large subscapular hematoma around the transplant kidney. The patient was observed to have renal trauma grade II at the hospital over a period of three days, and he was finally transferred to a transplant center after his urine output significantly decreased. Doppler ultrasound demonstrated an extensive peri-allograft hypoechoic area and abnormal waveforms with absent arterial diastolic flow and a patent renal vein. Despite surgical decompression, the allograft failed to respond appropriately due to the delay in surgical intervention. This is the third reported case of allograft loss from acute Page kidney following kidney transplantation. This case reinforces that kidney care differs if the kidney is solitary or a transplant. Early recognition and aggressive treatments are mandatory, especially in a case with Doppler signs that are suggestive of compression.

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          Most cited references27

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          Page kidney as a rare cause of hypertension: case report and review of the literature.

          Page kidney occurs by extrinsic compression of the renal parenchyma from a hematoma or a mass, leading to activation of the renin-angiotensin-aldosterone system and resulting in systemic hypertension. There have been about 100 cases of Page phenomenon reported in the literature. A review of cases published prior to 1991 revealed that football and nonsports-related trauma were the most common causes of Page kidney. Thereafter, 28 cases have been reported in the literature, including our case report presented here. These recent cases show that the etiology of Page kidney has shifted, perhaps because of the procedure-oriented current practice of medicine and the increased frequency of kidney transplant biopsies. In addition, management options have evolved, given the more frequent use of medications that block the renin-angiotensin-aldosterone system and the availability of less invasive procedures. Page kidney should be considered in the differential diagnosis of secondary hypertension.
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            Page kidney--a review of the literature.

            Page kidney was first described in animal experiments in 1939. In the 1950s and 1960s the human counterpart became evident. In this review we examine the modest literature on this rare but important renal/urological complication, summarize the clinical features, and discuss the best approach to diagnosis and management.
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              An unusual presentation of a Page kidney 24 days after transplantation: case report.

              The Page kidney phenomenon is a well recognized entity where an extrinsically compressed kidney results in hypertension and loss of function. This compression is usually caused by a subcapsular hematoma secondary to blunt abdominal trauma or an invasive procedure such as a renal biopsy. We describe an unusual case involving the spontaneous development of a Page kidney 24 days after renal transplantation without any history of preceding trauma. The subcapsular hematoma was detected by a computerized tomographic scan performed as part of the work-up for acute allograft dysfunction. Prompt recognition and early intervention are essential if renal function is to be restored before irreversible damage occurs.
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                Author and article information

                Journal
                World J Transplant
                WJT
                World Journal of Transplantation
                Baishideng Publishing Group Inc
                2220-3230
                24 February 2017
                24 February 2017
                : 7
                : 1
                : 88-93
                Affiliations
                Kazuhiro Takahashi, Krishna G Putchakayala, William J Kane, Jason E Denny, Dean Y Kim, Lauren E Malinzak, Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI 48202, United States
                Rohini Prashar, Nephrology and Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, United States
                Author notes

                Author contributions: Takahashi K, Prashar R and Malinzak LE designed the report; Takahashi K, Putchakayala KG and Kane WJ collected the data; Takahashi K and Malinzak LE wrote the paper; Denny JE and Kim DY performed critical revisions of the paper.

                Correspondence to: Lauren E Malinzak, MD, Transplant and Hepatobiliary Surgery, Henry Ford Hospital, 2790 West Grand Boulevard, Detroit, MI 48202, United States. lmalinz1@ 123456hfhs.org

                Telephone: +1-313-9162941 Fax: +1-313-9164353

                Article
                jWJT.v7.i1.pg88
                10.5500/wjt.v7.i1.88
                5324033
                c193857d-d36a-4d16-a478-ee5ecc4bb76c
                ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

                This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                : 30 October 2016
                : 19 December 2016
                : 11 January 2017
                Categories
                Case Report

                page kidney,kidney transplantation,trauma,subcapsular hematoma,doppler ultrasound

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