Human autophagy measurement: an underappreciated barrier to translation.

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Abstract

Preclinical research shows that autophagy is a modifiable process that holds promise for preventing human age-related disease. However, this knowledge has not been clinically translated. Here, we discuss recent developments in the ability to measure human autophagy, and why it is a critical step for translation.

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Journal

Journal ID (iso-abbrev): Trends Mol Med

Title: Trends in molecular medicine

Publisher: Elsevier BV

ISSN (Electronic): 1471-499X

ISSN (Print): 1471-4914

Publication date (Electronic): Dec 2021

Volume: 27

Issue: 12

Affiliations

[1 ] Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. Electronic address: Tim.Sargeant@sahmri.com.

[2 ] Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

Article

Publisher Item ID: S1471-4914(21)00251-3

DOI: 10.1016/j.molmed.2021.09.003

PubMed ID: 34629294

SO-VID: c12efbb3-7a6b-4417-b020-04d8183ab99a

History

Keywords: translation,human,blood,autophagy,autophagic flux,ageing

Data availability:

Keywords: translation, human, blood, autophagy, autophagic flux, ageing

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