Preeclampsia is one of the most common complications of pregnancy that is very difficult to control and manage during the outbreak of COVID-19. One way to control and manage this disease is to use self-care applications. Therefore, the aim of this study was to design and develop a mobile-based application to facilitate self-care for women, who suffer from pregnancy poisoning in the COVID-19 pandemic. This study was conducted in two stages: In the first stage, according to the opinion of 20 obstetricians and pregnant women, a needs assessment was performed. In the second stage, based on the identified needs, the application prototype was designed and then evaluated. For evaluation, 20 pregnant women were asked to use the application for 10 days. QUIS questionnaire version 5.5 was used for evaluation. Descriptive statistics and mann-whitney test in SPSS software version 23 were used for data analysis. Out of the 66 information needs that were identified via the questionnaire, 58 were considered in designing the application. Features of the designed application were placed in 5 categories: User’s profile, lifestyle, disease prevention and control, application capabilities and user’s satisfaction. The capabilities of the application consist of introducing specialized COVID-19 medical centers, search for the location of medical centers and doctors’ offices, drug management, drug allergies, self-assessment, stress reduction and control, nutrition and diet management, sleep management, doctor’s appointment reminders, communication with other patients and physicians, application settings. Pregnant women rated the usability of the application at a good level. The designed application can reduce the anxiety and stress due to preeclampsia feel and also improve their knowledge as well as attitude towards the COVID-19 pandemic and preeclampsia.