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      Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder

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          Abstract

          An elderly male with Bipolar Affective Disorder (BPAD) developed reversible ototoxicity, manifesting as bilateral sensory-neural hearing loss (SNHL) with administration of olanzapine.

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          Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide.

          F Cianfrone, D Pentangelo, G Cianfrone … (2011)
          The present work on drug-induced ototoxicity, tinnitus and vertigo represents the update and revision of a previous guide to adverse drug reactions for italian physicians (2005). The panorama of drug-induced side effects causing ototoxicity or symptoms such as tinnitus or dizziness and vertigo has enlarged in recent years, thanks to a better knowledge and a more specific attention of pharmaceutical firms and drug-control institutions. In daily clinical practice, there is a need for the family physician and the ENT specialist or audiologist (also in consideration of the possible medico-legal implications) to focus the attention on the possible risk of otological side effects. This would allow a clinical risk-benefit evaluation, weighing the possible clinical advantage in their field of competence against possible otological side-effects. The list of active ingredients and drugs is subdivided in categories based on their audiological and otoneurological side-effects, that have been signaled by the drug companies and/or ministerial notes. Drugs have also been subcategorized with regards to the field in which they are applied, the therapeutic indications and the clinical behaviour. They have also been organized in alphabetical order, for an easier consultation. The guide above, even if initially conceived for being used in Italy, also presents a more general and international interest, expecially as for as the concepts of pharmacology and the features of the active ingredients are concerned. The guide is, therefore, useful as for as we are concerned to any physician, regardless of the country he/she operates in.
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            Carbamazepine-induced sensorineural hearing loss.

            M. de la Cruz Ruiz, M L Bance (1999)
            Carbamazepine is a commonly prescribed anticonvulsant medication that affects various levels of the nervous system. We report a case of temporary sensorineural hearing loss in a patient after overdosing with 36 g of carbamazepine. Six days after the overdose, the patient complained of bilateral hearing loss and tinnitus. Audiograms revealed a 30- to 40-dB sensorineural hearing loss bilaterally. Another audiogram 2 weeks later showed a complete recovery in both ears accompanied by a clinical resolution in audiovestibular symptoms. Carbamazepine is used to treat partial and generalized seizures, trigeminal neuralgia, and bipolar illness. Adverse effects are not common but most frequently include dizziness, drowziness, nausea, and skin rashes; rare complications are agranulocytosis, bradycardia, and heart block. Documented hearing loss as a side effect of carbamazepine has not been reported, to our knowledge.
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              Sensorineural hearing loss: a reversible effect of valproic acid.

              Megan P. Miller, Mary E. Brown, Yung C. Shin … (1990)
              We report 2 patients over the age of 70 who, while on valproate (VPA) for complex partial seizures, developed sensorineural hearing loss. Following discontinuation of VPA for nonaudiologic reasons, the patients reported improved hearing which was confirmed by audiometry. These findings represent VPA-induced sensorineural hearing loss, possibly in preexisting presbycusis.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Pharmacol
                Journal ID (iso-abbrev): Indian J Pharmacol
                Journal ID (publisher-id): IJPharm
                Title: Indian Journal of Pharmacology
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 0253-7613
                ISSN (Electronic): 1998-3751
                Publication date (Print): Jul-Aug 2014
                Volume: 46
                Issue: 4
                Pages: 453-454
                Affiliations
                [1]Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, New Delhi, India
                Author notes
                Correspondence to: Dr. Sumit Kumar Gupta, E-mail: drsumit@ 123456aol.in
                Article
                Publisher ID: IJPharm-46-453
                DOI: 10.4103/0253-7613.135966
                PMC ID: 4118547
                SO-VID: c0ff780d-1841-4bb6-942f-b90cd65061da
                Copyright © Copyright: © Indian Journal of Pharmacology
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 09 March 2014
                Date revision received : 10 April 2014
                Date accepted : 11 June 2014
                Categories
                Subject: Drug Watch

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: olanzapine,bipolar affective disorder,ototoxicity
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: olanzapine, bipolar affective disorder, ototoxicity

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