Jakub G. Sobiecki:
ORCID: https://orcid.org/0000-0003-2641-2313
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Fumiaki Imamura:
ORCID: https://orcid.org/0000-0002-6841-8396
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Courtney R. Davis:
ORCID: https://orcid.org/0000-0002-3866-2603
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Stephen J. Sharp:
ORCID: https://orcid.org/0000-0003-2375-1440
Role: InvestigationRole: MethodologyRole: SupervisionRole: Writing – review & editing
Albert Koulman:
ORCID: https://orcid.org/0000-0001-9998-051X
Role: Data curationRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing
– review & editing
Jonathan M. Hodgson:
ORCID: https://orcid.org/0000-0001-6184-7764
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Marcela Guevara:
ORCID: https://orcid.org/0000-0001-9242-6364
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Matthias B. Schulze:
ORCID: https://orcid.org/0000-0002-0830-5277
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Ju-Sheng Zheng:
ORCID: https://orcid.org/0000-0001-6560-4890
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Claudia Agnoli:
ORCID: https://orcid.org/0000-0003-4472-1179
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Catalina Bonet: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Sandra M. Colorado-Yohar:
ORCID: https://orcid.org/0000-0002-6700-0780
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Guy Fagherazzi:
ORCID: https://orcid.org/0000-0001-5033-5966
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Paul W. Franks:
ORCID: https://orcid.org/0000-0002-0520-7604
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Thomas E. Gundersen: Role: Data curationRole: InvestigationRole: ResourcesRole: Writing – review & editing
Franziska Jannasch:
ORCID: https://orcid.org/0000-0003-3478-4758
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Rudolf Kaaks: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Verena Katzke:
ORCID: https://orcid.org/0000-0002-6509-6555
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Esther Molina-Montes:
ORCID: https://orcid.org/0000-0002-0428-2426
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Peter M. Nilsson:
ORCID: https://orcid.org/0000-0002-5652-8459
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Domenico Palli: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Salvatore Panico: Role: ConceptualizationRole: InvestigationRole: ResourcesRole: Writing – review &
editing
Keren Papier:
ORCID: https://orcid.org/0000-0002-4102-6835
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Olov Rolandsson: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Carlotta Sacerdote:
ORCID: https://orcid.org/0000-0002-8008-5096
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Anne Tjønneland:
ORCID: https://orcid.org/0000-0003-4385-2097
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Tammy Y. N. Tong:
ORCID: https://orcid.org/0000-0002-0284-8959
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Yvonne T. van der Schouw:
ORCID: https://orcid.org/0000-0002-4605-435X
Role: InvestigationRole: ResourcesRole: Writing – review & editing
John Danesh: Role: Funding acquisitionRole: InvestigationRole: ResourcesRole: Writing – review
& editing
Adam S. Butterworth:
ORCID: https://orcid.org/0000-0002-6915-9015
Role: Funding acquisitionRole: InvestigationRole: ResourcesRole: Writing – review
& editing
Elio Riboli:
ORCID: https://orcid.org/0000-0001-6795-6080
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: Writing – review & editing
Karen J. Murphy: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: Writing – review & editing
Nicholas J. Wareham:
ORCID: https://orcid.org/0000-0003-1422-2993
Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: Writing – review & editing
Nita G. Forouhi:
ORCID: https://orcid.org/0000-0002-5041-248X
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Barry M. Popkin: Role: Academic Editor
Funded by:
National Health and Medical Research Council
Award ID: #APP1050949
Award Recipient
:
Karen J. Murphy
Funded by:
funder-id http://dx.doi.org/10.13039/501100004965, Sixth Framework Programme;
Award ID: LSHM_CT_2006_037197
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
MRC Cambridge Initiative
Award ID: RG71466
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
MRC Cambridge Initiative
Award ID: SJAH/004
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MR/L003120/1
Award Recipient
:
John Danesh
Funded by:
funder-id http://dx.doi.org/10.13039/501100000274, British Heart Foundation;
Award ID: RG/13/13/30194
Award Recipient
:
John Danesh
Funded by:
funder-id http://dx.doi.org/10.13039/501100000274, British Heart Foundation;
Award ID: RG/18/13/33946
Award Recipient
:
John Danesh
Funded by:
funder-id http://dx.doi.org/10.13039/100011102, Seventh Framework Programme;
Award ID: HEALTH-F2-2012-279233
Award Recipient
:
John Danesh
Funded by:
European Research Council
Award ID: 268834
Award Recipient
:
John Danesh
Funded by:
funder-id http://dx.doi.org/10.13039/501100018956, NIHR Cambridge Biomedical Research Centre;
Award ID: IS-BRC-1215-20014
Award Recipient
:
ORCID: https://orcid.org/0000-0002-5041-248X
Nita G. Forouhi
Funded by:
Health Data Research UK
Award Recipient
:
John Danesh
Funded by:
funder-id http://dx.doi.org/10.13039/100008700, Centre International de Recherche sur le Cancer;
Funded by:
funder-id http://dx.doi.org/10.13039/501100014534, School of Public Health, Imperial College London;
Funded by:
funder-id http://dx.doi.org/10.13039/501100013342, NIHR Imperial Biomedical Research Centre;
Funded by:
Danish Cancer Society
Funded by:
funder-id http://dx.doi.org/10.13039/501100004099, Ligue Contre le Cancer;
Funded by:
funder-id http://dx.doi.org/10.13039/501100008017, Institut Gustave-Roussy;
Funded by:
Mutuelle Générale de l’Education Nationale
Funded by:
Institut National de la Santé et de la Recherche Médicale (INSERM)
Funded by:
German Cancer Aid
Funded by:
German Cancer Research Center
Funded by:
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)
Funded by:
funder-id http://dx.doi.org/10.13039/501100002347, Bundesministerium für Bildung und Forschung;
Funded by:
funder-id http://dx.doi.org/10.13039/501100006695, Associazione Iblea per la Ricerca Epidemiologica;
Funded by:
funder-id http://dx.doi.org/10.13039/501100005010, Associazione Italiana per la Ricerca sul Cancro;
Funded by:
funder-id http://dx.doi.org/10.13039/100007388, Compagnia di San Paolo;
Funded by:
National Research Council and Sicilian Regional Government
Funded by:
funder-id http://dx.doi.org/10.13039/501100002999, Ministerie van Volksgezondheid, Welzijn en Sport;
Funded by:
Netherlands Cancer Registry
Funded by:
LK Research Funds
Funded by:
Dutch Prevention Funds
Funded by:
Zorg Onderzoek Nederland
Funded by:
funder-id http://dx.doi.org/10.13039/501100013514, Wereld Kanker Onderzoek Fonds;
Funded by:
Statistics Netherlands
Funded by:
funder-id http://dx.doi.org/10.13039/501100004587, Instituto de Salud Carlos III;
Funded by:
Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra
Funded by:
Catalan Institute of Oncology
Funded by:
Swedish Cancer Society
Funded by:
Swedish Research Council
Funded by:
Councils of Skåne and Västerbotten
Funded by:
funder-id http://dx.doi.org/10.13039/501100000289, Cancer Research UK;
Award ID: 14136
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
funder-id http://dx.doi.org/10.13039/501100000289, Cancer Research UK;
Award ID: C8221/A29017
Funded by:
funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: 1000143
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MR/M012190/1
Funded by:
funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MC_UU_00006/1
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MC_UU_00006/3
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1422-2993
Nicholas J. Wareham
Funded by:
Federal Ministry of Education and Research and the State of Brandenburg
Award ID: DZD grant 82DZD03D03
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0830-5277
Matthias B. Schulze
Funded by:
funder-id http://dx.doi.org/10.13039/100018928, Westlake University;
Award ID: YSYY0209
Award Recipient
:
ORCID: https://orcid.org/0000-0001-6560-4890
Ju-Sheng Zheng
Funded by:
funder-id http://dx.doi.org/10.13039/100010665, H2020 Marie Skłodowska-Curie Actions;
Award ID: 701708
Award Recipient
:
ORCID: https://orcid.org/0000-0001-6560-4890
Ju-Sheng Zheng
Funded by:
funder-id http://dx.doi.org/10.13039/501100004191, Novo Nordisk;
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0520-7604
Paul W. Franks
Funded by:
Swedish Diabetes Association
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0520-7604
Paul W. Franks
Funded by:
Swedish Heart-Lung Foundation
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0520-7604
Paul W. Franks
Funded by:
European Research Council
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0520-7604
Paul W. Franks
Funded by:
Imperial College Biomedical Research Centre
Award Recipient
:
ORCID: https://orcid.org/0000-0001-6795-6080
Elio Riboli
The MedLey trial was funded by a National Health and Medical Research Council Grant
(#APP1050949 to KJM). The InterAct project was funded by the EU FP6 programme (grant
number LSHM_CT_2006_037197 to NJW). Biomarker measurements for carotenoids were funded
jointly by the InterAct project, the EPIC-CVD project, and the MRC Cambridge Initiative
(RG71466 and SJAH/004 to NJW, NGF, JD, AB). EPIC-CVD has been supported by the UK
Medical Research Council (MR/L003120/1 to ASB and JD), the British Heart Foundation
(RG/13/13/30194 and RG/18/13/33946 to ASB and JD), the European Commission Framework
Programme 7 (HEALTH-F2-2012-279233 to ASB and JD), the European Research Council (268834
to ASB and JD), and the National Institute for Health Research (NIHR; Cambridge Biomedical
Research Centre at the Cambridge University Hospitals NHS Foundation Trust, BRC-1215-20014
to ASB and JD). This work was also supported by Health Data Research UK (to ASB and
JD), which is funded by the UK Medical Research Council, Engineering and Physical
Sciences Research Council, Economic and Social Research Council, Department of Health
and Social Care (England), Chief Scientist Office of the Scottish Government Health
and Social Care Directorates, Health and Social Care Research and Development Division
(Welsh Government), Public Health Agency (Northern Ireland), and Wellcome. The coordination
of EPIC is financially supported by the International Agency for Research on Cancer
(IARC) and also by the Department of Epidemiology and Biostatistics, School of Public
Health, Imperial College London which has additional infrastructure support provided
by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported
by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy,
Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la
Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center
(DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry
of Education and Research (BMBF) (Germany); Associazione Iblea Ricerca Epidemiologica
(A.I.R.E. – ONLUS) Ragusa, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy,
Compagnia di San Paolo, National Research Council and Sicilian Regional Government
(Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer
Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek
Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands);
Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments
of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute
of Oncology - ICO (Spain); Swedish Cancer Society, Swedish Research Council and County
Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to NJW; C8221/A29017),
Medical Research Council (1000143 to NJW; MR/M012190/1) (United Kingdom). JGS was
supported by the MRC PhD studentship. NJW, NGF, and FI acknowledge funding from the
Medical Research Council Epidemiology Unit (MC_UU_00006/1, MC_UU_00006/3); and NJW,
NGF and AK from the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014;
NIHR203312). NGF and JD are NIHR Senior Investigators. JD holds a British Heart Foundation
Professorship. MBS acknowledges funding from the Federal Ministry of Education and
Research and the State of Brandenburg (DZD grant 82DZD03D03). JSZ has received funding
from Westlake University (No YSYY0209) and European Union’s Horizon 2020 research
and innovation programme under the Marie Skłodowska-Curie grant agreement No 701708.
PWF has received funding from Novo Nordisk, Swedish Diabetes Association, Swedish
Heart-Lung Foundation, European Research Council. ER has received funding from Imperial
College Biomedical Research Centre. The funders of the studies had no role in the
study design, data collection, data analysis, data interpretation, or report preparation.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Diet and Type 2 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Diet and Type 2 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Fatty Acids
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials
Subject:
Pigments
Subject:
Organic Pigments
Subject:
Carotenoids
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Trials
Subject:
Randomized Controlled Trials
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Drug Research and Development
Subject:
Clinical Trials
Subject:
Randomized Controlled Trials
Subject:
Research and Analysis Methods
Subject:
Clinical Trials
Subject:
Randomized Controlled Trials
Subject:
Medicine and Health Sciences
Subject:
Epidemiology