Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.

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Abstract

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

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Journal

Journal ID (iso-abbrev): J. Virol.

Title: Journal of virology

Publisher: American Society for Microbiology

ISSN (Electronic): 1098-5514

ISSN (Print): 0022-538X

Publication date (Electronic): Jan 13 2016

Volume: 90

Issue: 7

Affiliations

[1 ] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

[2 ] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA florian.krammer@mssm.edu ronghai@ucr.edu.

[3 ] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Article

Publisher Item ID: JVI.03060-15

DOI: 10.1128/JVI.03060-15

PMC ID: 4794680

PubMed ID: 26764009

SO-VID: c054c623-ad39-4214-9f17-96489773a8ea

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