For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
29
views
166
references
 Top references
cited by
101
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      474
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic, and antinflammatory properties of its metabolic products, HO-1 plays a key role in healthy cells in maintaining redox homeostasis and in preventing carcinogenesis. Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed. In this review, we summarize the current literature regarding the pro-tumorigenic role of HO-1 dependent tumor progression as a promising target in anticancer strategy.

          Related collections

          Most cited references166

          • Record: found
          • Abstract: found
          • Article: not found

          Distinct role of macrophages in different tumor microenvironments.

          Claire Lewis, Jeffrey W Pollard (2006)
          Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes.
          Article 0 comments Cited 667 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

            Matthew Kraman, Paul J Bambrough, James Arnold … (2010)
            The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein-α (FAP). We created a transgenic mouse in which FAP-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-γ and tumor necrosis factor-α. Depleting FAP-expressing cells in a subcutaneous model of pancreatic ductal adenocarcinoma also permitted immunological control of growth. Therefore, FAP-expressing cells are a nonredundant, immune-suppressive component of the tumor microenvironment.
            Article 0 comments Cited 427 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Macrophages in Tumor Microenvironments and the Progression of Tumors

              Zhiren Zhang, Ning-Bo Hao, Mu-Han Lü … (2012)
              Macrophages are widely distributed innate immune cells that play indispensable roles in the innate and adaptive immune response to pathogens and in-tissue homeostasis. Macrophages can be activated by a variety of stimuli and polarized to functionally different phenotypes. Two distinct subsets of macrophages have been proposed, including classically activated (M1) and alternatively activated (M2) macrophages. M1 macrophages express a series of proinflammatory cytokines, chemokines, and effector molecules, such as IL-12, IL-23, TNF- α , iNOS and MHCI/II. In contrast, M2 macrophages express a wide array of anti-inflammatory molecules, such as IL-10, TGF- β , and arginase1. In most tumors, the infiltrated macrophages are considered to be of the M2 phenotype, which provides an immunosuppressive microenvironment for tumor growth. Furthermore, tumor-associated macrophages secrete many cytokines, chemokines, and proteases, which promote tumor angiogenesis, growth, metastasis, and immunosuppression. Recently, it was also found that tumor-associated macrophages interact with cancer stem cells. This interaction leads to tumorigenesis, metastasis, and drug resistance. So mediating macrophage to resist tumors is considered to be potential therapy.
              Article 0 comments Cited 366 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Debasis Mondal: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Antioxidants (Basel)
                Journal ID (iso-abbrev): Antioxidants (Basel)
                Journal ID (publisher-id): antioxidants
                Title: Antioxidants
                Publisher: MDPI
                ISSN (Electronic): 2076-3921
                Publication date (Electronic): 05 May 2017
                Publication date Collection: June 2017
                Volume: 6
                Issue: 2
                Electronic Location Identifier: 29
                Affiliations
                [1 ]Department of Experimental Medicine, University of Genoa, Via L. B. Alberti 2, Genoa 16132, Italy; Mariapaola.Nitti@ 123456unige.it (M.N.); piras.sabri@ 123456tiscali.it (S.P.); umm@ 123456unige.it (U.M.M.); maidep@ 123456unige.it (M.A.P.)
                [2 ]Bambino Gesù Children’s Hospital, IRCCS, Piazza S. Onofrio 4, Rome 00165, Italy; Lorenzo.Moretta@ 123456opbg.net
                [3 ]Giannina Gaslini Institute, IRCCS, Via Gerolamo Gaslini 5, Genoa 16147, Italy
                Author notes
                [* ]Correspondence: annalisa.furfaro@ 123456unige.it ; Tel.:+39-010-353-8831
                Article
                Publisher ID: antioxidants-06-00029
                DOI: 10.3390/antiox6020029
                PMC ID: 5488009
                PubMed ID: 28475131
                SO-VID: bfcec120-050c-44f4-976e-a009c9404c55
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 31 March 2017
                Date accepted : 29 April 2017
                Categories
                Subject: Review

                Keywords: ho-1,nrf2,cancer progression,tumor microenvironment,immune-escape,oxidative stress,nk,melanoma,nsclc,prostate cancer
                Data availability:
                Keywords: ho-1, nrf2, cancer progression, tumor microenvironment, immune-escape, oxidative stress, nk, melanoma, nsclc, prostate cancer

                Comments

                Comment on this article

                scite_

                Similar content474

                See all similar

                Cited by99

                See all cited by

                Most referenced authors2,572

                See all reference authors