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      Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

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          Abstract

          The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology due to its feasibility, low toxicity, eco‐friendly nature, and long‐term viability. Some plants have long been used in medicine because they contain a variety of bioactive compounds. Silver has long been known for its antibacterial properties. Silver nanoparticles have taken a special place among other metal nanoparticles. Silver nanotechnology has a big impact on medical applications like bio‐coating, novel antimicrobial agents, and drug delivery systems. This review aims to provide a comprehensive understanding of the pharmaceutical qualities of medicinal plants, as well as a convenient guideline for plant‐based silver nanoparticles and their antimicrobial activity.

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          Most cited references207

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          Mitochondria and apoptosis.

          D Green, J Reed (1998)
          A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.
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            The bactericidal effect of silver nanoparticles.

            Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
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              Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.

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                Author and article information

                Contributors
                tsathiamoorthi@gmail.com
                bioinfosaran@gmail.com
                Journal
                IET Nanobiotechnol
                IET Nanobiotechnol
                10.1049/(ISSN)1751-875X
                NBT2
                IET Nanobiotechnology
                John Wiley and Sons Inc. (Hoboken )
                1751-8741
                1751-875X
                15 April 2022
                June 2022
                : 16
                : 4 ( doiID: 10.1049/nbt2.v16.4 )
                : 115-144
                Affiliations
                [ 1 ] Medical Microbiology Unit Department of Microbiology Alagappa University Karaikudi Tamilnadu India
                [ 2 ] Chimertech Private Limited Chennai Tamilnadu India
                [ 3 ] Centre for Materials Engineering and Regenerative Medicine Bharath Institute of Higher Education and Research Chennai Tamilnadu India
                [ 4 ] Division of Biomedical Sciences College of Health Sciences School of Medicine Mekelle Ethiopia
                [ 5 ] AMR and Nanotherapeutics Laboratory Department of Pharmacology Saveetha Dental College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamilnadu India
                Author notes
                [*] [* ] Correspondence

                Saravanan Muthupandian, AMR and Nanotherapeutics Laboratory, Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamilnadu, India.

                Email: bioinfosaran@ 123456gmail.com

                Sathiamoorthi Thangavelu, Medical Microbiology Unit, Department of Microbiology, Alagappa University, Karaikudi, Tamilnadu 630 003, India.

                Email: tsathiamoorthi@ 123456gmail.com

                Author information
                https://orcid.org/0000-0002-2054-0907
                https://orcid.org/0000-0003-0472-8077
                https://orcid.org/0000-0001-6506-1953
                https://orcid.org/0000-0003-1316-8526
                https://orcid.org/0000-0002-1404-4499
                https://orcid.org/0000-0003-2677-7064
                https://orcid.org/0000-0002-1480-3555
                Article
                NBT212078
                10.1049/nbt2.12078
                9114445
                35426251
                bf8d1df0-8387-45cd-a1da-f1a8769a9713
                © 2022 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 07 January 2022
                : 02 June 2021
                : 14 February 2022
                Page count
                Figures: 8, Tables: 6, Pages: 30, Words: 19802
                Categories
                Review
                Review
                Custom metadata
                2.0
                June 2022
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.6 mode:remove_FC converted:18.05.2022

                antimicrobial,eco‐friendly,green synthesis,silver nanoparticles

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