Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

This study aims to explore the relationship between PI3K/AKT/mTOR signaling pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA).

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Biomed. Pharmacother.

Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Publisher: Elsevier BV

ISSN (Electronic): 1950-6007

ISSN (Print): 0753-3322

Publication date (Electronic): May 2017

Volume: 89

Affiliations

[1 ] Department of Orthopedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.

[2 ] Department of Orthopedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China. Electronic address: shi_zhm@126.com.

Article

Publisher Item ID: S0753-3322(16)31199-4

DOI: 10.1016/j.biopha.2017.01.130

PubMed ID: 28320092

SO-VID: bf58258d-ef9c-446b-9421-623b0c300572

History

Keywords: Autophagy,IL-1β,Induction,Osteoarthritis,PI3K/AKT/mTORi,Rat articular chondrocytes

Data availability:

Keywords: Autophagy, IL-1β, Induction, Osteoarthritis, PI3K/AKT/mTORi, Rat articular chondrocytes

Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis.

Read this article at

Abstract

Related collections

Neuronal Signaling

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Cited by 192