Cerebral Perfusion and the Risk of Dementia: A Population-Based Study.

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Abstract

Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion with subsequent cognitive decline and development of dementia.

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Author and article information

Journal

Journal ID (iso-abbrev): Circulation

Title: Circulation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4539

ISSN (Print): 0009-7322

Publication date (Electronic): Aug 22 2017

Volume: 136

Issue: 8

Affiliations

[1 ] From Department of Epidemiology (F.J.W., H.I.Z., A.H., M.W.V., M.A.I.), Department of Neurology (F.J.W., P.J.K., M.A.I.), Department of Radiology and Nuclear Medicine (H.I.Z., A.v.d.L., M.W.V., M.A.I.), Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (F.J.W., A.H.).

[2 ] From Department of Epidemiology (F.J.W., H.I.Z., A.H., M.W.V., M.A.I.), Department of Neurology (F.J.W., P.J.K., M.A.I.), Department of Radiology and Nuclear Medicine (H.I.Z., A.v.d.L., M.W.V., M.A.I.), Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (F.J.W., A.H.). m.a.ikram@erasmusmc.nl.

Article

Publisher Item ID: CIRCULATIONAHA.117.027448

DOI: 10.1161/CIRCULATIONAHA.117.027448

PubMed ID: 28588075

SO-VID: bf55a675-b0f1-4be2-9209-a38bab6fe830

History

Keywords: cerebral blood flow,dementia,small-vessel disease,cerebral perfusion,Alzheimer disease,epidemiology

Data availability:

Keywords: cerebral blood flow, dementia, small-vessel disease, cerebral perfusion, Alzheimer disease, epidemiology

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