Non-Enhanced MR Imaging of Cerebral Aneurysms: 7 Tesla versus 1.5 Tesla

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Abstract

Purpose

To prospectively evaluate 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) in comparison to 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of unruptured intracranial aneurysms (UIA).

Material and Methods

Sixteen neurosurgical patients (male n = 5, female n = 11) with single or multiple UIA were enrolled in this trial. All patients were accordingly examined at 7 Tesla and 1.5 Tesla MRI utilizing dedicated head coils. The following sequences were obtained: 7 Tesla TOF MRA, 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced MPRAGE. Image analysis was performed by two radiologists with regard to delineation of aneurysm features (dome, neck, parent vessel), presence of artifacts, vessel-tissue-contrast and overall image quality. Interobserver accordance and intermethod comparisons were calculated by kappa coefficient and Lin's concordance correlation coefficient.

Results

A total of 20 intracranial aneurysms were detected in 16 patients, with two patients showing multiple aneurysms (n = 2, n = 4). Out of 20 intracranial aneurysms, 14 aneurysms were located in the anterior circulation and 6 aneurysms in the posterior circulation. 7 Tesla MPRAGE imaging was superior over 1.5 and 7 Tesla TOF MRA in the assessment of all considered aneurysm and image quality features (e.g. image quality: mean MPRAGE7T: 5.0; mean TOF7T: 4.3; mean TOF1.5T: 4.3). Ratings for 7 Tesla TOF MRA were equal or higher over 1.5 Tesla TOF MRA for all assessed features except for artifact delineation (mean TOF7T: 4.3; mean TOF1.5T 4.4). Interobserver accordance was good to excellent for most ratings.

Conclusion

7 Tesla MPRAGE imaging demonstrated its superiority in the detection and assessment of UIA as well as overall imaging features, offering excellent interobserver accordance and highest scores for all ratings. Hence, it may bear the potential to serve as a high-quality diagnostic tool for pretherapeutic assessment and follow-up of untreated UIA.

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Most cited references 25

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Author and article information

Contributors

Zhuoli Zhang: Role: Editor

Journal

Journal ID (nlm-ta): PLoS One

Journal ID (iso-abbrev): PLoS ONE

Journal ID (publisher-id): plos

Journal ID (pmc): plosone

Title: PLoS ONE

Publisher: Public Library of Science (San Francisco, USA )

ISSN (Electronic): 1932-6203

Publication date Collection: 2014

Publication date (Electronic): 6 January 2014

Volume: 9

Issue: 1

Electronic Location Identifier: e84562

Affiliations

[1 ]Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany

[2 ]Department of Neurosurgery, University Hospital Essen, Essen, Germany

[3 ]Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany

Northwestern University Feinberg School of Medicine, United States of America

Author notes

* E-mail: karsten.wrede@ 123456uk-essen.de

Competing Interests: The authors have declared that no competing interests exist.

Conceived and designed the experiments: KHW PD CM SJ SM IES OM NÖ MEL MF MUS US LU. Performed the experiments: KHW PD CM SJ SM IES OM NÖ MEL MF MUS US LU. Analyzed the data: KHW PD CM SJ SM IES OM NÖ MEL MF MUS US LU. Contributed reagents/materials/analysis tools: KHW PD CM LU. Wrote the paper: KHW PD CM SJ SM IES OM NÖ MEL MF MUS US LU.

Article

Publisher ID: PONE-D-13-35793

DOI: 10.1371/journal.pone.0084562

PMC ID: 3882245

PubMed ID: 24400100

SO-VID: be6c9206-e276-4eee-9855-a9feb10054ec

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

History

Date received : 31 August 2013

Date accepted : 22 November 2013

Page count

Pages: 10

Funding

An IFORES grant to KHW from the University Duisburg-Essen supported the research [ http://www.uni-due.de/med/forschung/forschungsfoerderung/ifores.shtml]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Non-Enhanced MR Imaging of Cerebral Aneurysms: 7 Tesla versus 1.5 Tesla

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Abstract

Purpose

Material and Methods

Results

Conclusion

Related collections

PLOS Climate

Most cited references 25

A concordance correlation coefficient to evaluate reproducibility.

Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature.

The intrinsic signal-to-noise ratio in NMR imaging.

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