Peritoneal Solvent Drag Reflection Coefficients Are within the Physiological Range – ScienceOpen
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      Peritoneal Solvent Drag Reflection Coefficients Are within the Physiological Range

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          Abstract

          Previous estimates of the peritoneal solvent drag reflection coefficient (σ) are widely disparate; some are outside the range expected for a semipermeable membrane (i.e., between 0 and 1). We have evaluated a novel method for determining σ in a rabbit model of peritoneal dialysis. Test solute was infused intravenously, and sequential 2-hour isotonic and hypertonic exchanges (40 ml/kg) were performed in random order. Test solute was also added to the instilled hypertonic dialysis solution to inhibit transperitoneal solute diffusion during this exchange. Eight experiments were performed with creatinine as test solute and glucose as osmotic solute, and six experiments were performed with glucose as test solute and mannitol as osmotic solute. When using isotonic dialysis solution, the dialysate/plasma concentration ratio (D/P) for both test solutes increased throughout the exchange (p < 0.001). When using hypertonic dialysis solution, D/P creatinine was initially near 1 and decreased during the 1st hour of the exchange (p < 0.05); D/P glucose (as test solute) was initially 0.82 ± (SEM) 0.07 and did not change during the exchange. The peritoneal diffusive permeability-area product (PA) was determined by fitting a mathematical model to the time dependence of the dialysate test solute concentration during the isotonic exchange using PA as an adjustable parameter, and σ was determined in like manner during the hypertonic exchange using σ as an adjustable parameter (and assuming a PA value equal to that during the isotonic exchange). The creatinine PA (1.37 ± 0.28 ml/min) was higher than that for glucose (0.62 ± 0.07 ml/min) as expected based on their solution diffusion coefficients. Creatinine and glucose σ values were 0.38 ± 0.06 and 0.43 ± 0.05, respectively. We conclude that peritoneal σ values for creatinine and glucose are within the physiological range.

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          Author and article information

          Journal
          BPU
          Blood Purif
          10.1159/issn.0253-5068
          Blood Purification
          S. Karger AG
          0253-5068
          1421-9735
          1994
          1994
          30 October 2008
          : 12
          : 6
          : 327-336
          Affiliations
          Research Service, Veterans Affairs Medical Center, and Departments of Internal Medicine and Bioengineering, University of Utah, Salt Lake City, Utah, USA
          Article
          170181 Blood Purif 1994;12:327–336
          10.1159/000170181
          7865191
          be29e7df-9ac1-4728-8f07-3a60bda2070b
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 16 May 1994
          Page count
          Pages: 10
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Convective solute transport,Diffusive solute transport,Hypertonic dialysis solution,New Zealand White rabbit,Peritoneal membrane,Solvent drag reflection coefficient,Ultrafiltration

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