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Clusters of cortical spreading depolarizations in a patient with intracerebral hemorrhage: a multimodal neuromonitoring study.
A J Schiefecker
1 ,
R Beer ,
B Pfausler ,
P Lackner ,
G Broessner ,
I Unterberger ,
F Sohm ,
M Mulino ,
C Thome ,
C Humpel ,
E Schmutzhard ,
R Helbok
Apr 2015
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Abstract
Spontaneous intracerebral hemorrhage (ICH) is associated with high morbidity and mortality. Cortical spreading depolarizations (CSDs) increase brain matrix metalloproteinase (MMP)-9 activity leading to perihematomal edema expansion in experimental ICH.