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      Integration of Moran’s I, geographically weighted regression (GWR), and ordinary least square (OLS) models in spatiotemporal modeling of COVID-19 outbreak in Qom and Mazandaran Provinces, Iran

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          Abstract

          Globally, the COVID-19 pandemic is a top-level public health concern. This paper attempts to identify the COVID-19 pandemic in Qom and Mazandaran provinces, Iran using spatial analysis approaches. This study was based on secondary data of confirmed cases and deaths from February 3, 2020, to late October 2021, in two Qom and Mazandaran provinces from hospitals and the website of the National Institute of Health. In this paper, three geographical models in ArcGIS 10.8.1 were utilized to analyze and evaluate COVID-19, including geographic weight regression (GWR), ordinary least squares (OLS), and spatial autocorrelation (Moran I). The results from this study indicate that the rate of scattering of confirmed cases for Qom province for the period was 44.25%, while the rate of dispersal of the deaths was 4.34%. Based on the GWR and OLS model, Moran’s statistics demonstrated that confirmed cases, deaths, and recovered followed a clustering pattern during the study period. Moran’s Z-score for all three indicators of confirmed cases, deaths, and recovered was confirmed to be greater than 2.5 (95% confidence level) for both GWR and OLS models. The spatial distribution of indicators of confirmed cases, deaths, and recovered based on the GWR model has been more scattered in the northwestern and southwestern cities of Qom province. Whereas the spatial distribution of the recoveries of the COVID-19 pandemic in Qom province was 61.7%, the central regions of this province had the highest spread of recoveries. The spatial spread of the COVID-19 pandemic from February 3, 2020, to October 2021 in Mazandaran province was 35.57%, of which 2.61% died, according to information published by the COVID-19 pandemic headquarters. Most confirmed cases and deaths are scattered in the north of this province. The ordinary least squares model results showed that the spatial dispersion of recovered people from the COVID-19 pandemic is more significant in the central and southern regions of Mazandaran province. The Z-score for the deaths Index is more significant than 14.314. The results obtained from this study and the information published by the National Headquarters for the fight against the COVID-19 pandemic showed that tourism and pilgrimages are possible factors for the spatial distribution of the COVID-19 pandemic in Qom and Mazandaran provinces. The spatial information obtained from these modeling approaches could provide general insights to authorities and researchers for further targeted investigations and policies in similar circumcises.

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          A pneumonia outbreak associated with a new coronavirus of probable bat origin

          Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
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            Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

            Summary Background In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. Methods In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020. Findings Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneumothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure. Interpretation The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. Funding National Key R&D Program of China.
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              Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

              Summary Background In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (2019-nCoV). As of Jan 26, 2020, more than 2000 cases of 2019-nCoV infection have been confirmed, most of which involved people living in or visiting Wuhan, and human-to-human transmission has been confirmed. Methods We did next-generation sequencing of samples from bronchoalveolar lavage fluid and cultured isolates from nine inpatients, eight of whom had visited the Huanan seafood market in Wuhan. Complete and partial 2019-nCoV genome sequences were obtained from these individuals. Viral contigs were connected using Sanger sequencing to obtain the full-length genomes, with the terminal regions determined by rapid amplification of cDNA ends. Phylogenetic analysis of these 2019-nCoV genomes and those of other coronaviruses was used to determine the evolutionary history of the virus and help infer its likely origin. Homology modelling was done to explore the likely receptor-binding properties of the virus. Findings The ten genome sequences of 2019-nCoV obtained from the nine patients were extremely similar, exhibiting more than 99·98% sequence identity. Notably, 2019-nCoV was closely related (with 88% identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21, collected in 2018 in Zhoushan, eastern China, but were more distant from SARS-CoV (about 79%) and MERS-CoV (about 50%). Phylogenetic analysis revealed that 2019-nCoV fell within the subgenus Sarbecovirus of the genus Betacoronavirus, with a relatively long branch length to its closest relatives bat-SL-CoVZC45 and bat-SL-CoVZXC21, and was genetically distinct from SARS-CoV. Notably, homology modelling revealed that 2019-nCoV had a similar receptor-binding domain structure to that of SARS-CoV, despite amino acid variation at some key residues. Interpretation 2019-nCoV is sufficiently divergent from SARS-CoV to be considered a new human-infecting betacoronavirus. Although our phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. Funding National Key Research and Development Program of China, National Major Project for Control and Prevention of Infectious Disease in China, Chinese Academy of Sciences, Shandong First Medical University.
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                Author and article information

                Contributors
                vahidisazade75@gmail.com
                qasimi.abdul.a@gmail.com , qasimi.abdul.a@smgu.edu.af
                pinliang.dong@unt.edu
                kaplangorde@gmail.com
                ismailisazadeh75@gmail.com
                Journal
                Model Earth Syst Environ
                Model Earth Syst Environ
                Modeling Earth Systems and Environment
                Springer International Publishing (Cham )
                2363-6203
                2363-6211
                15 February 2023
                : 1-15
                Affiliations
                [1 ]Department of Geographical Sciences, Khwarazm University, Tehran, Iran
                [2 ]Department of Geography, Education Faculty, Samangan University, Samangan, Afghanistan
                [3 ]GRID grid.266869.5, ISNI 0000 0001 1008 957X, Department of Geography and the Environment, , University of North Texas, ; 1155 Union Circle, Denton, #305279 TX 76203 USA
                [4 ]GRID grid.502985.3, ISNI 0000 0004 6881 4051, Institute of Earth and Space Sciences, , Eskisehir Technical University, ; Eskişehir, Turkey
                [5 ]GRID grid.412265.6, ISNI 0000 0004 0406 5813, Department of Urban planning, , Kharazmi University, ; Tehran, Iran
                Author information
                http://orcid.org/0000-0001-9180-831X
                Article
                1729
                10.1007/s40808-023-01729-y
                9930702
                bd7187f6-c361-41bc-ad8c-f01ced285794
                © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 13 December 2022
                : 24 January 2023
                Categories
                Original Article

                covid-19,geographically weighted regression,least squares model,spatial autocorrelation,qom,mazandaran

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