9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Endocrine autoimmune diseases and female infertility.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          An increasing body of evidence suggests that immune-mediated processes affect female reproductive success at multiple levels. Crosstalk between endocrine and immune systems regulates a large number of biological processes that affect target tissues, and this crosstalk involves gene expression, cytokine and/or lymphokine release and hormone action. In addition, endocrine-immune interactions have a major role in the implantation process of the fetal (paternally derived) semi-allograft, which requires a reprogramming process of the maternal immune system from rejection to temporary tolerance for the length of gestation. Usually, the female immune system is supportive of all of these processes and, therefore, facilitates reproductive success. Abnormalities of the female immune system, including autoimmunity, potentially interfere at multiple levels. The relevance of the immune system to female infertility is increasingly recognized by investigators, but clinically is often not adequately considered and is, therefore, underestimated. This Review summarizes the effect of individual autoimmune endocrine diseases on female fertility, and points towards selected developments expected in the near future.

          Related collections

          Author and article information

          Journal
          Nat Rev Endocrinol
          Nature reviews. Endocrinology
          Springer Science and Business Media LLC
          1759-5037
          1759-5029
          Jan 2014
          : 10
          : 1
          Affiliations
          [1 ] The Center for Human Reproduction (CHR), 21 East 69th Street, New York, NY 10021, USA.
          Article
          nrendo.2013.212
          10.1038/nrendo.2013.212
          24189508
          bd5071b8-86d7-4cf5-8890-97352c053a08
          History

          Comments

          Comment on this article