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      Short-Term Effects of a Conditioning Telerehabilitation Program in Confined Patients Affected by COVID-19 in the Acute Phase. A Pilot Randomized Controlled Trial

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          Abstract

          Background and objectives: The COVID-19 pandemic has become a challenge for health systems and, specifically, to physical therapists obligated to adapt their job and stop face-to-face consultations. In this situation, therapeutic exercise has been implemented in different COVID-19 patients. This study evaluated the feasibility and effectiveness of a novel therapeutic exercise program through telerehabilitation tools in COVID-19 patients with mild to moderate symptomatology in the acute stage. Materials and Methods: A total of 40 subjects were randomized an experimental group, based on muscle conditioning, and in a control group, who did not perform physical activity. Thirty-six subjects, 18 in each group, completed the one-week intervention. We measured the six-minute walking test, multidimensional dyspnoea-12, thirty seconds sit-to-stand test, and Borg Scale. Results: Both groups were comparable at baseline. Statistically significant improvement between groups ( p < 0.05) in favor of the experimental group was obtained. No differences between gender were found ( p > 0.05). Ninety percent adherence was found in our program. Conclusion: A one-week telerehabilitation program based on muscle toning exercise is effective, safe, and feasible in COVID-19 patients with mild to moderate symptomatology in the acute stage.

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          Wuhan coronavirus (2019-nCoV): The need to maintain regular physical activity while taking precautions

          The on-going Wuhan coronavirus (2019-novel coronavirus, 2019-nCoV) outbreak in China has become the world's leading health headline and is causing major panic and public concerns. On January 30, 2020, the World Health Organization (WHO) declared that the new coronavirus outbreak is a public health emergency of international concern. 1 The virus has already had a direct impact on more than 10 million people in the city of Wuhan and has reached other parts of China as well, posing a health threat of unknown magnitude globally. As of February 8, 2020, WHO reported 34,886 confirmed cases of 2019-nCoV globally, with 34,589 of them occurring in China (including 6101 severe cases and 723 deaths). A total of 288 other confirmed cases (with 1 death) have been reported in 24 countries, including Japan, Australia, Germany, and United States. 2 However, these daily estimates are expected to rise even higher as reports from health authorities in China 3 are gathered and near real-time updates of the Johns Hopkins virus dashboard are made. 4 The outbreak has caused governments in various countries to take swift and protective measures. In China, these included putting cities on lockdown, 5 implementing travel warnings/bans and cancellations, 6 extending national holidays, and closing schools and postponing classes. 7 Currently, there is no vaccine for the prevention or treatment of the illness caused by the virus; its origins and the ultimate extent of this epidemic remain unknown. There have been more than 50 research papers published within the last 20 days 8 that have allowed for the rapid sharing of scientific information about the virus, but serious questions regarding the causes or mechanisms of transmission, incubation period, risk assessments, and options for effective treatment or intervention of the virus remain largely unanswered. 9 There have been reports of significant shortages of medical staff, a lack of clinics that can handle and treat infected patients, and high demands for face masks for protection. The Chinese central government is working with extraordinary diligence to mobilize resources, including building new hospitals and developing new coronavirus vaccine, as well as sending medical experts and clinicians to the city of Wuhan 10 to help contain the highly transmittable virus outbreak from spreading further. With the continuing coronavirus spur, the public has been advised by various health authorities to reduce traveling and stay at home as a basic means of limiting people's exposure to the virus. Health authorities, including the National Health Commission of the People's Republic of China, 11 WHO, 12 and U.S Centers for Disease Control and Prevention, 13 have issued safety recommendations for taking simple precautions to reduce exposure to and transmission of the virus. Unfortunately, the mandated restrictions on travel and directives against participating in outdoor activities, including regular physical activity and exercise, will inevitably disrupt the routine daily activities of tens of millions of people. While containing the virus as quickly as possible is the urgent public health priority, there have been few public health guidelines for the public as to what people can or should do in terms of maintaining their daily exercise or physical activity routines. Arguably, staying home, while a safe measure, may have unintended negative consequences since such efforts to avoid human-to-human transmission of the virus may lead to reduced physical activity. It is likely that prolonged home stay may lead to increased sedentary behaviors, such as spending excessive amounts of time sitting, reclining, or lying down for screening activities (playing games, watching television, using mobile devices); reducing regular physical activity (hence lower energy expenditure); or engaging in avoidance activities that, consequently, lead to an increased risk for and potential worsening of chronic health conditions. 14 Therefore, there is a strong health rationale for continuing physical activity in the home to stay healthy and maintain immune system function in the current precarious environment. Exercise at home using various safe, simple, and easily implementable exercises is well suited to avoid the airborne coronavirus and maintain fitness levels. Such forms of exercise may include, but are not limited to, strengthening exercises, activities for balance and control, stretching exercises, or a combination of these. Examples of home exercises include walking in the house and to the store as necessary, lifting and carrying groceries, alternating leg lunges, stair climbing, stand-to-sit and sit-to-stand using a chair and from the floor, chair squats, and sit-ups and pushups. In addition, traditional Tai Ji Quan, Qigong exercises, 15 and yoga 16 should be considered since they require no equipment, little space, and can be practiced at any time. The use of eHealth and exercise videos, which focuses on encouraging and delivering physical activity through the Internet, mobile technologies, and television 17 are other viable avenues for maintaining physical function and mental health during this critical period. Official measures that restrict people's movements in the presence of the coronavirus crisis do not necessarily mean that physical activity must be limited or that all forms of exercise must be eliminated entirely. Exercise has been shown to have clear health benefits for healthy individuals 18 and for patients with various diseases. 19 In this respect, we strongly echo Dr. Steven Blair's quote from Dr. Ken Powell: “Some activity is better than none, and more is better than less” (p. 525). 20 The aim should be to undertake at least 30 min of moderate physical activity every day and/or at least 20 min of vigorous physical activity every other day. 18 Ideally, a combination of both intensities of physical activities is preferable in addition to practicing strengthening-type activities on a regular basis. 18 Children, the elderly, and those who have previously experienced symptoms of illness or are susceptible to chronic cardiovascular or pulmonary disease should seek advice from health care providers about when it is safe to exercise. Given the concerns about the increasing spread of 2019-nCoV, it is imperative that infection control and safety precautions be followed. Home stay is a fundamental safety step that can limit infections from spreading widely. But prolonged home stays can increase behaviors that lead to inactivity and contribute to anxiety and depression, which in turn can lead to a sedentary lifestyle known to result in a range of chronic health conditions. Maintaining regular physical activity and routinely exercising in a safe home environment is an important strategy for healthy living during the coronavirus crisis.
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            The compelling link between physical activity and the body's defense system

            Highlights • Acute exercise is an immune system adjuvant that improves defense activity and metabolic health. • Data support a clear inverse relationship between moderate exercise training and illness risk. • Exercise training has an anti-inflammatory influence mediated through multiple pathways. • Illness risk is increased in athletes during periods of intensified training and competition. • Increased carbohydrate and polyphenol intake is an effective nutritional strategy for immune support. • Habitual exercise improves immune regulation, delaying the onset of age-related dysfunction. • Advances in mass spectrometry technology will provide new insights on exercise–immune responses.
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              Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

              Background The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments. Findings At 2–3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p<0.0001 to 0.044). Interpretation A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness. Funding NIHR Oxford and Oxford Health Biomedical Research Centres, British Heart Foundation Centre for Research Excellence, UKRI, Wellcome Trust, British Heart Foundation.
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                Author and article information

                Contributors
                Role: Academic Editor
                Role: Academic Editor
                Journal
                Medicina (Kaunas)
                Medicina (Kaunas)
                medicina
                Medicina
                MDPI
                1010-660X
                1648-9144
                03 July 2021
                July 2021
                : 57
                : 7
                : 684
                Affiliations
                [1 ]Department of Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain; cleofas@ 123456us.es
                [2 ]Department of Nursing, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain; clinicafisiosur@ 123456gmail.com (J.J.G.-G.); clinicasaavedra@ 123456yahoo.es (M.S.-H.)
                [3 ]Doctoral Program in Health Sciences, University of Seville, 41009 Seville, Spain; anartelazo.ernesto@ 123456gmail.com
                [4 ]Physician in Intensive Medicine in the Spanish Army, Health Support in the Naval Base of Rota, 11520 Cádiz, Spain; manuel.manuelale@ 123456gmail.com
                Author notes
                [* ]Correspondence: cbernal495@ 123456gmail.com
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-8674-9180
                https://orcid.org/0000-0002-6235-8353
                https://orcid.org/0000-0002-9731-9039
                Article
                medicina-57-00684
                10.3390/medicina57070684
                8305888
                34356965
                bcd38f2e-8473-44e6-8eb3-e47905a813a9
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                : 25 May 2021
                : 30 June 2021
                Categories
                Article

                covid-19,physical therapy,telerehabilitation,exercise therapy

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