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      Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment

      , ,
      Cancer Discovery
      American Association for Cancer Research (AACR)

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          Abstract

          Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype to treat. To date, therapies directed to specific molecular targets have rarely achieved clinically meaningful improvements in outcomes of patients with TNBC, and chemotherapy remains the standard-of-care. Here we seek to review the most recent efforts to classify TNBC based on comprehensive profiling of tumors for cellular composition and molecular features. Technological advances allow for tumor characterization at ever increasing depth, generating data that, if integrated with clinical-pathologic features, may help improve risk stratification of patients, guide treatment decisions and surveillance, and help identify new targets for drug development.

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          Author and article information

          Journal
          Cancer Discovery
          Cancer Discov
          American Association for Cancer Research (AACR)
          2159-8274
          2159-8290
          February 08 2019
          February 2019
          February 2019
          January 24 2019
          : 9
          : 2
          : 176-198
          Article
          10.1158/2159-8290.CD-18-1177
          6387871
          30679171
          bc759f9e-4706-4128-96c9-ccf1d8d8cde8
          © 2019
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