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      Portraying infective endocarditis: results of multinational ID-IRI study.

      1 , 2 , 3 , 4 , 5 , 3 , 3 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 6 , 4 , 6 , 4 , 18 , 4 , 19 , 20 , 21 , 22 , 23 , 21 , 7 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 25 , 35 , 26 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 28 , 41 , 43 , 44 , 45 , 46 , 47 , 47
      European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
      Springer Science and Business Media LLC
      Blood culture, Infective endocarditis, Native, Prosthetic, S. aureus

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          Abstract

          Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

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          Author and article information

          Journal
          Eur J Clin Microbiol Infect Dis
          European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
          Springer Science and Business Media LLC
          1435-4373
          0934-9723
          Sep 2019
          : 38
          : 9
          Affiliations
          [1 ] IDI-IRI, Ankara, Turkey. hakanerdem1969@yahoo.com.
          [2 ] Department of Infectious Diseases, University Hospital Center "Mother Teresa", Tirana, Albania.
          [3 ] Department of Infectious Diseases, Strasbourg University Hospital, Nouvel Hôpital Civil, Strasbourg, France.
          [4 ] Infectious Diseases Department, Centro Hospitalar São João and Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
          [5 ] Institute of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.
          [6 ] Ataturk Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University, Ankara, Turkey.
          [7 ] Clinical & Research Department for Infectious Diseases, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS,, Via Portuense, 292, 00149, Rome, Italy.
          [8 ] Department of Cardiovascular Surgery, Strasbourg University Hospital, Nouvel Hôpital Civil, Strasbourg, France.
          [9 ] Service of Infectious Disease, UHC, Tirana, Albania.
          [10 ] Department of Infectious Diseases and Clinical Microbiology, Tepecik Training and Research Hospital, Izmir, Turkey.
          [11 ] Department of Infectious Diseases and Clinical Microbiology, Dr. Lutfi Kirdar Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
          [12 ] Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
          [13 ] Department of Microbiology, Atilim University, School of Medicine, Ankara, Turkey.
          [14 ] Department of Infectious Diseases and Clinical Microbiology, Pendik Medical Park Hospital, Istanbul, Turkey.
          [15 ] Shifa International Hospital and Shifa Tameer-e-Millat University, Islamabad, Pakistan.
          [16 ] Department of Cardiology, Gulhane Training and Research Hospital, Health Sciences University, Ankara, Turkey.
          [17 ] Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University School of Medicine, Istanbul, Turkey.
          [18 ] Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Health Sciences University, Antalya, Turkey.
          [19 ] Department of Medicine, Infectious Diseases Division, King Saud University Hospital, Riyadh, Saudi Arabia.
          [20 ] Department of Infectious Diseases and Clinical Microbiology, Corlu State Hospital, Tekirdag, Antalya, Turkey.
          [21 ] Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université libre de Bruxelles (ULB), 322 rue Haute, 1000, Brussels, Belgium.
          [22 ] Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
          [23 ] Department of Infectious Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
          [24 ] Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
          [25 ] Department of Infectious Diseases, School of Medicine, The University of Jordan, Amman, Jordan.
          [26 ] Dr Victor Babes Clinical Hospital of Infectious and Tropical Disease, Bucharest, Romania.
          [27 ] Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
          [28 ] Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey.
          [29 ] Department of Infectious Diseases, UMC Ljubljana, Ljubljana, Slovenia.
          [30 ] Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy.
          [31 ] Clinical Infectious Diseases Hospital, Ovidius University of Constanta, Constanta, Romania.
          [32 ] Department of Pathology, Kecioren Training and Research Hospital, Ankara, Turkey.
          [33 ] Department of Infectious Diseases and Clinical Microbiology, Mersin University School of Medicine, Mersin, Turkey.
          [34 ] Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, Izmir, Turkey.
          [35 ] Department of Infectious Disease and Clinical Microbiology, Izzet Baysal University School of Medicine, Bolu, Turkey.
          [36 ] Department of Infectious Diseases and Clinical Microbiology, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey.
          [37 ] Department of Infectious Diseases and Clinical Microbiology, Cigli Regional Education Hospital, Izmir, Turkey.
          [38 ] Department of Intensive Care Unit, Turkey Advanced Specialty Education and Research Hospital, Ankara, Turkey.
          [39 ] Department of Infectious Diseases and Clinical Microbiology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
          [40 ] Department of Infectious Disease and Clinical Microbiology, Usak University School of Medicine, Usak, Turkey.
          [41 ] Department of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
          [42 ] Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
          [43 ] Department of Infectious Diseases and Clinical Microbiology, Onsekiz Mart University School of Medicine, Canakkale, Turkey.
          [44 ] Department of Nephrology, American Hospital, Tirana, Albania.
          [45 ] Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
          [46 ] Department of Clinical and Molecular Biomedicine, Section of Infectious Diseases, University of Catania, Catania, Italy.
          [47 ] Department of Infectious Diseases and Clinical Microbiology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
          Article
          10.1007/s10096-019-03607-x
          10.1007/s10096-019-03607-x
          31187307
          bbdd187a-aeb1-45d1-bdd3-96266ccb2c35
          History

          Blood culture,Infective endocarditis,Native,Prosthetic,S. aureus

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