[Aptameric DNA--a new type of thrombin inhibitor].

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Abstract

The formation of complexes between various thrombin preparations and a 30-mer aptamer DNA was comparatively studied, and a correlation between the complex formation and the fibrinogen-hydrolyzing activity of thrombin was found. The aptamer DNA was shown to inhibit the fibrin formation from fibrinogen.

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Journal

Journal ID (iso-abbrev): Bioorg Khim

Title: Bioorganicheskaia khimiia

Publisher: Springer Science and Business Media LLC

ISSN: 0132-3423

ISSN (Print): 0132-3423

Publication date (Electronic): November 7 2003

Volume: 29

Issue: 5

Affiliations

[1 ] Belozersky Institute of Physicochemical Biology, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia. spiridon@genebee.msu.su

Article

DOI: 10.1023/a:1026001609421

PubMed ID: 14601404

SO-VID: bbbb4499-d087-42b1-9559-f5f7e4a9bb1c

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