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Substantia nigra lesion protects against ischemic damage in the striatum
October 1987
October 1987
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Abstract
The role of striatal dopamine (DA) in mediating ischemic neuronal death was studied
in the rat. Two weeks after unilateral substantia nigra lesion, rats were subjected
to 20 min of forebrain ischemia by 4-vessel occlusion. Morphological changes and 45Ca
uptake were evaluated after 3 days of survival. In the DA-depleted striatum, the degree
of ischemic neuronal damage and 45Ca uptake were markedly attenuated compared to the
contralateral side. This study is the first to demonstrate that the presence of DA
is a prerequisite for the development of ischemic injury in the striatum and that
DA depletion protects the striatum from ischemic damage.
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