Cellular apoptosis and cardiac dysfunction in STZ-induced diabetic rats attenuated by anthocyanins via activation of IGFI-R/PI3K/Akt survival signaling.

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Abstract

Anthocyanins are known cyto-protective agents against various stress conditions. In this study cardio-protective effect of anthocyanins from black rice against diabetic mellitus (DM) was evaluated using a streptozotocin (STZ)-induced DM rat model. Five-week-old male Wistar rats were administered with STZ (55 mg kg-1 , IP) to induce DM; rats in the treatment group received 250 mg oral anthocyanin/kg/day during the 4-week treatment period. DM and the control rats received normal saline through oral gavage. The results reveal that STZ-induced DM elevates myocardial apoptosis and associated proapoptotic proteins but down-regulates the proteins of IGF1R mediated survival signaling mechanism. Furthermore, the functional parameters such as the ejection-fraction and fraction-shortening in the DM rat hearts declined considerably. However, the rats treated with anthocyanins significantly reduced apoptosis and the associated proapoptotic proteins and further increased the survival signals to restore the cardiac functions in DM rats. Anthocyanin supplementation enhances cardiomyocyte survival and restores cardiac function.

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Author and article information

Journal

Journal ID (iso-abbrev): Environ. Toxicol.

Title: Environmental toxicology

Publisher: Wiley

ISSN (Electronic): 1522-7278

ISSN (Print): 1520-4081

Publication date (Electronic): Dec 2017

Volume: 32

Issue: 12

Affiliations

[1 ] Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.

[2 ] Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.

[3 ] Department of Biotechnology, Asia University, Taichung, Taiwan.

[4 ] Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

[5 ] Department of cardiology, Asia University and Asia University Hospital, Taichung, Taiwan.

[6 ] Department of Biotechnology, Bharathiar University, Coimbatore, 641 046, India.

[7 ] Division of Cardiology, Department of Internal Medicine, Taichung Armed Force General Hospital, Taichung, Taiwan.

[8 ] Department of Healthcare Administration, Asia University, Taichung, Taiwan.

[9 ] Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.

[10 ] Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.

Article

DOI: 10.1002/tox.22460

PubMed ID: 28856781

SO-VID: bb76b6cc-064b-458d-a515-38793acb7881

History

Keywords: cardiac apoptosis,diabetes mellitus,anthocyanin,streptozotocin,IGFI-R

Data availability:

Keywords: cardiac apoptosis, diabetes mellitus, anthocyanin, streptozotocin, IGFI-R

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