Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

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Abstract

Purpose

To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model.

Methods

In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. Corneal epithelial integrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14. Histologic and immunohistochemistry findings were also assessed.

Results

Both the 0.5% and 1.0% RCI001 groups showed significantly more epithelial healing compared to the control group at day 5, 7, 10, and 14 (each p < 0.05). No statistical difference was found between the 0.5% and 1.0% RCI001 groups. Neither the Solcoseryl nor the PDRN groups showed a significant difference from the control. RCI001 treatment resulted in significantly reduced stromal edema, and a trend towards less inflammatory cell infiltration.

Conclusions

Topical application of RCI001 showed enhanced corneal epithelial wound healing in the murine corneal alkali burn model, presumably by suppressing inflammation. Meanwhile, Solcoseryl and PDRN did not show sufficient therapeutic effects compared to RCI001.

Related collections

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Author and article information

Journal

Journal ID (nlm-ta): Korean J Ophthalmol

Journal ID (iso-abbrev): Korean J Ophthalmol

Title: Korean Journal of Ophthalmology : KJO

Publisher: Korean Ophthalmological Society

ISSN (Print): 1011-8942

ISSN (Electronic): 2092-9382

Publication date (Print): June 2023

Publication date (Electronic): 5 June 2023

Volume: 37

Issue: 3

Pages: 236-244

Affiliations

[1 ]Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

[2 ]RudaCure Co., Ltd, Incheon, Korea

[3 ]Gachon Pain Center, Gachon University College of Medicine, Incheon, Korea

[4 ]Department of Physiology, Gachon University College of Medicine, Incheon, Korea

[5 ]Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea

Author notes

Corresponding Author: Dong Hyun Kim, MD, PhD. Department of Ophthalmology, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea. Tel: 82-2-920-5366, Fax: 82-2-924-6820, Email: amidfree@ 123456gmail.com

Article

Publisher ID: kjo-2023-0019

DOI: 10.3341/kjo.2023.0019

PMC ID: 10270771

PubMed ID: 37309557

SO-VID: bad00d87-ab64-4a82-89b7-b1ecf875f38a

License:

This is an Open Access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 24 February 2023

Date revision received : 15 May 2023

Date accepted : 22 May 2023

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