Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT.

Dietz, Andreas; Sabri, Osama; Stumpp, Patrick; Purz, Sandra; Müller, Stefan; Fischer, Miloš; Wichmann, Gunnar; Krüger, Anne; Boehm, Andreas; Kolb, Marlen; Hofer, Mathias; Kluge, Regine

doi:10.1016/j.ejca.2016.11.013

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Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT.

Author(s): Gunnar Wichmann ¹ , Anne Krüger ² , Andreas Boehm ² , Marlen Kolb ² , Mathias Hofer ² , Milos Fischer ² , Stefan Müller ² , Sandra Purz ³ , Patrick Stumpp ⁴ , Osama Sabri ³ , Andreas Dietz ² , Regine Kluge ³

Publication date (Electronic): February 2017

Journal: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

Keywords: (18)F-FDG, Decision-making, Early response evaluation, HNSCC, Head and neck cancer, Hypopharyngeal cancer, Induction chemotherapy, Laryngeal cancer, Larynx preservation, PET/CT

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Abstract

Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS.

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Journal ID (iso-abbrev): Eur. J. Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): February 2017

Volume: 72

Affiliations

[1 ] Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany. Electronic address: gunnar.wichmann@medizin.uni-leipzig.de.

[2 ] Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany.

[3 ] Department of Nuclear Medicine, University of Leipzig, Germany.

[4 ] Department of Diagnostic and Interventional Radiology, University of Leipzig, Germany.

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Publisher Item ID: S0959-8049(16)32591-6

DOI: 10.1016/j.ejca.2016.11.013

PubMed ID: 28033526

SO-VID: ba94ec6b-b8ba-40d3-99b8-50707abd7715

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Keywords: Induction chemotherapy,Laryngeal cancer,Larynx preservation,PET/CT,(18)F-FDG,Decision-making,Early response evaluation,HNSCC,Head and neck cancer,Hypopharyngeal cancer

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Keywords: Induction chemotherapy, Laryngeal cancer, Larynx preservation, PET/CT, (18)F-FDG, Decision-making, Early response evaluation, HNSCC, Head and neck cancer, Hypopharyngeal cancer

Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT.

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