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      Tannic Acid as a Green Cross-linker for Biomaterial Applications

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          Abstract

          Abstract:

          Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial, and cross-linking agent in biomaterial products due to its unique functional groups. Its active phenolic groups can react with biomaterial functional groups to form bonds that improve performance. In this review, the mechanism of effectiveness of tannic acid as a natural crosslinker in improving the properties of biomaterials for various applications, such as tissue engineering, tissue adhesives, drug delivery, wound healing, and toxicity studies, has been investigated. In general, tannic acid can be a suitable alternative to synthetic crosslinkers in biomaterial applications.

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          A reversible wet/dry adhesive inspired by mussels and geckos.

          Haeshin Lee, Bruce P Lee, Phillip B. Messersmith (2007)
          The adhesive strategy of the gecko relies on foot pads composed of specialized keratinous foot-hairs called setae, which are subdivided into terminal spatulae of approximately 200 nm (ref. 1). Contact between the gecko foot and an opposing surface generates adhesive forces that are sufficient to allow the gecko to cling onto vertical and even inverted surfaces. Although strong, the adhesion is temporary, permitting rapid detachment and reattachment of the gecko foot during locomotion. Researchers have attempted to capture these properties of gecko adhesive in synthetic mimics with nanoscale surface features reminiscent of setae; however, maintenance of adhesive performance over many cycles has been elusive, and gecko adhesion is greatly diminished upon full immersion in water. Here we report a hybrid biologically inspired adhesive consisting of an array of nanofabricated polymer pillars coated with a thin layer of a synthetic polymer that mimics the wet adhesive proteins found in mussel holdfasts. Wet adhesion of the nanostructured polymer pillar arrays increased nearly 15-fold when coated with mussel-mimetic polymer. The system maintains its adhesive performance for over a thousand contact cycles in both dry and wet environments. This hybrid adhesive, which combines the salient design elements of both gecko and mussel adhesives, should be useful for reversible attachment to a variety of surfaces in any environment.
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            A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

            Elbadawy Kamoun, El-Refaie Kenawy, Xin-Xin Chen (2017)
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              A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

              M. Reddy, Deepalekshmi Ponnamma, Rajan Choudhary … (2021)
              Tissue engineering (TE) and regenerative medicine integrate information and technology from various fields to restore/replace tissues and damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or as cellular systems for drugs and cells; thereby, cellular material is able to colonize host cells sufficiently to meet up the requirements of regeneration and repair. This process is multi-stage and requires the development of various components to create the desired neo-tissue or organ. In several current TE strategies, biomaterials are essential components. While several polymers are established for their use as biomaterials, careful consideration of the cellular environment and interactions needed is required in selecting a polymer for a given application. Depending on this, scaffold materials can be of natural or synthetic origin, degradable or nondegradable. In this review, an overview of various natural and synthetic polymers and their possible composite scaffolds with their physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, and porosity are discussed. The scaffolds fabrication techniques and a few commercially available biopolymers are also tabulated.
              Article 0 comments Cited 173 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Mini-Reviews in Medicinal Chemistry
                Abbreviated Title: MRMC
                Publisher: Bentham Science Publishers Ltd.
                ISSN (Print): 13895575
                Publication date Created: July 2023
                Publication date (Print): July 2023
                Volume: 23
                Issue: 13
                Pages: 1320-1340
                Affiliations
                [1 ]Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
                [2 ]Tissue Engineering Group, Department of Biomedical Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
                [3 ]Department of Tissue Engineering, Tissuehub Co., Tehran, Iran
                [4 ] Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, Iran.
                [5 ]Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
                [6 ]Biomaterials Group, School of Metallurgy and Materials Engineering, Iran University of Science & Technology, Tehran, Iran.
                Article
                DOI: 10.2174/1389557522666220622112959
                PubMed ID: 35733304
                SO-VID: ba5bca32-cdaa-46fb-ada9-4cf727121a98
                Copyright © © 2023
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