20
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Radiomics optimizing the evaluation of endometrial receptivity for women with unexplained recurrent pregnancy loss

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          The optimization of endometrial receptivity (ER) through individualized therapies has been shown to enhance the likelihood of successful gestation. However, current practice lacks comprehensive methods for evaluating the ER of patients with recurrent pregnancy loss (RPL). Radiomics, an emerging AI-based technique that enables the extraction of mineable information from medical images, holds potential to offer a more objective and quantitative approach to ER assessment. This innovative tool may facilitate a deeper understanding of the endometrial environment and enable clinicians to optimize ER evaluation in RPL patients.

          Objective

          This study aimed to identify ultrasound radiomics features associated with ER, with the purpose of predicting successful ongoing pregnancies in RPL patients, and to assess the predictive accuracy of these features against regular ER parameters.

          Methods

          This retrospective, controlled study involved 262 patients with unexplained RPL and 273 controls with a history of uncomplicated full-term pregnancies. Radiomics features were extracted from ultrasound endometrial segmentation images to derive a radiomics score (rad-score) for each participant. Associations between rad-scores, baseline clinical variables, and sonographic data were evaluated using univariate and multivariate logistic regression analyses to identify potential indicators of RPL. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive accuracy of the rad-score and other identified indicators in discriminating RPL cases. Furthermore, the relationships between age and these identified indicators were assessed via Pearson correlation analysis.

          Results

          From the 1312 extracted radiomics features, five non-zero coefficient radiomics signatures were identified as significantly associated with RPL, forming the basis of the rad-score. Following multivariate logistic regression analysis, age, spiral artery pulsatility index (SA-PI), vascularisation index (VI), and rad-score emerged as independent correlates of RPL (all P<0.05). ROC curve analyses revealed the superior discriminative capability of the rad-score (AUC=0.882) over age (AUC=0.778), SA-PI (AUC=0.771), and VI (AUC=0.595). There were notable correlations between age and rad-score (r=0.275), VI (r=-0.224), and SA-PI (r=0.211), indicating age-related variations in RPL predictors.

          Conclusion

          This study revealed a significant association between unexplained RPL and elevated endometrial rad-scores during the WOI. Furthermore, it demonstrated the potential of rad-scores as a promising predictive tool for successful ongoing pregnancies in RPL patients.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: found
          • Article: not found

          Radiomics: Images Are More than Pictures, They Are Data

          This report describes the process of radiomics, its challenges, and its potential power to facilitate better clinical decision making, particularly in the care of patients with cancer.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Introduction to Radiomics

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Recurrent miscarriage.

              Many human conceptions are genetically abnormal and end in miscarriage, which is the commonest complication of pregnancy. Recurrent miscarriage, the loss of three or more consecutive pregnancies, affects 1% of couples trying to conceive. It is associated with psychological morbidity, and has often proven to be frustrating for both patient and clinician. A third of women attending specialist clinics are clinically depressed, and one in five have levels of anxiety that are similar to those in psychiatric outpatient populations. Many conventional beliefs about the cause and treatment of women with recurrent miscarriage have not withstood scrutiny, but progress has been made. Research has emphasised the importance of recurrent miscarriage in the range of reproductive failure linking subfertility and late pregnancy complications and has allowed us to reject practice based on anecdotal evidence in favour of evidence-based management.
                Bookmark

                Author and article information

                Contributors
                Journal
                Front Endocrinol (Lausanne)
                Front Endocrinol (Lausanne)
                Front. Endocrinol.
                Frontiers in Endocrinology
                Frontiers Media S.A.
                1664-2392
                08 August 2023
                2023
                : 14
                : 1181058
                Affiliations
                [1]Department of Ultrasound Imaging, The First People’s Hospital of Wenling , Wenling, Zhejiang, China
                Author notes

                Edited by: Xinmei Liu, Fudan University, China

                Reviewed by: Wassan Nori, Mustansiriyah University, Iraq; Ban Hameed, Mustansiriyah University, Iraq

                *Correspondence: Mengjie Liang, 444143915@ 123456qq.com

                †ORCID: Mengjie Liang, orcid.org/0000-0002-9268-4133

                Article
                10.3389/fendo.2023.1181058
                10545880
                37795355
                ba5835b0-4526-429a-aab1-59326ca0bc1d
                Copyright © 2023 Huang, Jin, Jiang and Liang

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 07 March 2023
                : 24 July 2023
                Page count
                Figures: 5, Tables: 2, Equations: 0, References: 39, Pages: 10, Words: 4523
                Funding
                Wenling Social Development Science and Technology Project (2022S00145).
                Categories
                Endocrinology
                Original Research
                Custom metadata
                Reproduction

                Endocrinology & Diabetes
                radiomics,recurrent pregnancy loss,endometrial receptivity,superfertile,ultrasound

                Comments

                Comment on this article