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      Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products.

      1 , , , ,
      Chemistry & biology
      Elsevier BV

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          Abstract

          Cultured soil microorganisms have provided a rich source of natural-product chemistry. Because only a tiny fraction of soil microbes from soil are readily cultured, soil might be the greatest untapped resource for novel chemistry. The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.

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          Author and article information

          Journal
          Chem Biol
          Chemistry & biology
          Elsevier BV
          1074-5521
          1074-5521
          Oct 1998
          : 5
          : 10
          Affiliations
          [1 ] Department of Plant Pathology, University of Wisconsin-Madison 53706, USA. joh@plantpath.wisc.edu
          Article
          S1074-5521(98)90108-9
          10.1016/s1074-5521(98)90108-9
          9818143
          b9a2ebd0-5af9-448a-9e35-cc2bafffc997
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