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      Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

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          Abstract

          <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d849768e99">Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti-inflammatory M2 macrophages such as tumor-associated macrophages (TAMs) promote tumor growth and invasion. Modulating the tumor immune microenvironment through engineering macrophages is efficacious in tumor therapy. M1 macrophages target cancerous cells and, therefore, can be used as drug carriers for tumor therapy. Herein, the strategies to engineer macrophages for cancer immunotherapy, such as inhibition of macrophage recruitment, depletion of TAMs, reprograming of TAMs, and blocking of the CD47-SIRPα pathway, are discussed. Further, the recent advances in drug delivery using M1 macrophages, macrophage-derived exosomes, and macrophage-membrane-coated nanoparticles are elaborated. Overall, there is still significant room for development in macrophage-mediated immune modulation and macrophage-mediated drug delivery, which will further enhance current tumor therapies against various malignant solid tumors, including drug-resistant tumors and metastatic tumors. </p>

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          Author and article information

          Contributors
          (View ORCID Profile)
          Journal
          Advanced Materials
          Adv. Mater.
          Wiley
          0935-9648
          1521-4095
          October 2020
          August 28 2020
          October 2020
          : 32
          : 40
          : 2002054
          Affiliations
          [1 ]Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University Xi'an Shaanxi 710126 China
          [2 ]Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Bethesda MD 20892 USA
          Article
          10.1002/adma.202002054
          32856350
          b86c9b08-d611-48e4-831a-4ebac9ec4ab2
          © 2020

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

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