A. Stefanie Mikolaizak: Role: ConceptualizationRole: MethodologyRole: Project administrationRole: Writing
– original draftRole: Writing – review & editing
Lynn Rochester: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: SupervisionRole: Writing – review & editing
Walter Maetzler: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: SupervisionRole:
Writing – review & editing
Basil Sharrack: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: SupervisionRole:
Writing – review & editing
Heleen Demeyer: Role: InvestigationRole: SupervisionRole: Writing – review & editing
Claudia Mazzà: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Brian Caulfield: Role: Data curationRole: Funding acquisitionRole: InvestigationRole: Project administrationRole:
SoftwareRole: Writing – review & editing
Judith Garcia-Aymerich: Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Writing – review & editing
Beatrix Vereijken: Role: Funding acquisitionRole: VisualizationRole: Writing – review & editing
Valdo Arnera: Role: Data curationRole: ResourcesRole: Writing – review & editing
Ram Miller: Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Paolo Piraino: Role: ResourcesRole: Writing – review & editing
Nadir Ammour: Role: Data curationRole: ResourcesRole: Writing – review & editing
Mark Forrest Gordon:
ORCID: https://orcid.org/0000-0002-0271-3050
Role: ResourcesRole: Writing – review & editing
Thierry Troosters: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: Writing
– review & editing
Alison J. Yarnall: Role: InvestigationRole: SupervisionRole: Writing – review & editing
Lisa Alcock:
ORCID: https://orcid.org/0000-0002-8364-9803
Role: InvestigationRole: SoftwareRole: Writing – review & editing
Heiko Gaßner: Role: Data curationRole: InvestigationRole: Project administrationRole: ValidationRole:
Writing – review & editing
Jürgen Winkler: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Jochen Klucken: Role: InvestigationRole: Project administrationRole: SupervisionRole: Writing – review
& editing
Christian Schlenstedt: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Henrik Watz: Role: InvestigationRole: SupervisionRole: Writing – review & editing
Anne-Marie Kirsten: Role: InvestigationRole: Project administrationRole: Writing – review & editing
Ioannis Vogiatzis: Role: Funding acquisitionRole: InvestigationRole: SupervisionRole: Writing – review
& editing
Nikolaos Chynkiamis:
ORCID: https://orcid.org/0000-0002-9595-6974
Role: InvestigationRole: Writing – review & editing
Emily Hume:
ORCID: https://orcid.org/0000-0003-0462-2395
Role: InvestigationRole: Writing – review & editing
Dimitrios Megaritis:
ORCID: https://orcid.org/0000-0001-6786-4346
Role: InvestigationRole: Writing – review & editing
Alice Nieuwboer: Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Pieter Ginis: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Ellen Buckley: Role: Data curationRole: InvestigationRole: Project administrationRole: Writing –
review & editing
Gavin Brittain: Role: InvestigationRole: Writing – review & editing
Giancarlo Comi: Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Letizia Leocani: Role: InvestigationRole: SupervisionRole: Writing – review & editing
Jorunn L. Helbostad: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: SupervisionRole:
Writing – review & editing
Lars Gunnar Johnsen: Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Kristin Taraldsen: Role: ConceptualizationRole: InvestigationRole: SupervisionRole: Writing – review
& editing
Hubert Blain: Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Valérie Driss: Role: InvestigationRole: Writing – review & editing
Anja Frei: Role: ConceptualizationRole: MethodologyRole: SupervisionRole: Writing – review &
editing
Milo A. Puhan: Role: Funding acquisitionRole: SupervisionRole: Writing – review & editing
Ashley Polhemus: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Magda Bosch de Basea: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Elena Gimeno: Role: InvestigationRole: Writing – review & editing
Nicholas S. Hopkinson:
ORCID: https://orcid.org/0000-0003-3235-0454
Role: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Sara C. Buttery: Role: InvestigationRole: Project administrationRole: Writing – review & editing
Jeffrey M. Hausdorff: Role: Funding acquisitionRole: MethodologyRole: SupervisionRole: Writing – review
& editing
Anat Mirelman:
ORCID: https://orcid.org/0000-0002-1520-2292
Role: MethodologyRole: Project administrationRole: SupervisionRole: Writing – review
& editing
Jordi Evers: Role: Data curationRole: Funding acquisitionRole: ResourcesRole: SoftwareRole: Writing
– review & editing
Isabel Neatrour: Role: Data curationRole: Project administrationRole: Writing – original draftRole:
Writing – review & editing
David Singleton: Role: Data curationRole: MethodologyRole: Project administrationRole: SoftwareRole:
Writing – review & editing
Lars Schwickert: Role: MethodologyRole: Writing – original draft
Clemens Becker: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
Carl-Philipp Jansen:
ORCID: https://orcid.org/0000-0002-2779-7019
Role: InvestigationRole: MethodologyRole: Project administrationRole: Writing – original
draftRole: Writing – review & editing
Thomas Phillips: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
6
October
2022
Publication date Collection: 2022
Volume: 17
Issue: 10
Electronic Location Identifier: e0269615
Affiliations
[1
]
Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany
[2
]
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle
University, Newcastle upon Tyne, United Kingdom
[3
]
Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany
[4
]
Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield
Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England,
United Kingdom
[5
]
Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
[6
]
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
[7
]
Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium
[8
]
Insigneo Institute, Department of Mechanical Engineering, University of Sheffield,
Sheffield, United Kingdom
[9
]
Insight Centre for Data Analytics, O’Brien Science Centre, University College Dublin,
Dublin, Ireland
[10
]
UCD School of Public Health, Physiotherapy and Sports Science University College Dublin,
Dublin, Ireland
[11
]
Barcelona Institute for Global Health (ISGlobal), Barcelona, Catalonia, Spain
[12
]
Universitat Pompeu Fabra (UPF), Barcelona, Spain
[13
]
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
[14
]
Department of Neuromedicine and Movement Science, Norwegian University of Science
and Technology, Trondheim, Norway
[15
]
Clario, Geneva, Switzerland
[16
]
Novartis Institutes for Biomedical Research, Cambridge, MA, United States of America
[17
]
Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany
[18
]
Clinical Science & Operations, Global Development, Sanofi R&D, Chilly-Mazarin, France
[19
]
Specialty Clinical Development, Teva Pharmaceuticals, West Chester, PA, United States
of America
[20
]
Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany
[21
]
Digital Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
[22
]
Institute of Interdisciplinary Exercise Science and Sports Medicine, Medical School
Hamburg, Hamburg, Germany
[23
]
Pulmonary Research Institute at LungClinic Grosshansdorf GmbH, Airway Research Center
North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
[24
]
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences,
Northumbria University, Newcastle, England
[25
]
Thorax Research Foundation & First Dept. of Respiratory Medicine, National & Kapodistrian
University of Athens, Sotiria General Chest Hospital, Athens, Greece
[26
]
KU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group
(eNRGy), Leuven, Belgium
[27
]
Department of Neurology, San Raffaele University, Milan, Italy
[28
]
Casa di Cura del Policlinico, Milan, Italy
[29
]
Department of Physiotherapy, Oslo Metropolitan University (OsloMet), Oslo, Norway
[30
]
Department of Geriatrics, Montpellier University Hospital and MUSE, Montpellier, France
[31
]
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich,
Switzerland
[32
]
National Heart and Lung Institute, Imperial College London, London, England
[33
]
Center for the Study of Movement, Cognition and Mobility, Neurological Institute,
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
[34
]
Department of Physical Therapy, Sackler Faculty of Medicine & Sagol School of Neuroscience,
Tel Aviv University, Tel Aviv, Israel
[35
]
Rush Alzheimer’s Disease Center and Department of Orthopaedic Surgery, Rush University
Medical Center, Chicago, Illinois, United States of America
[36
]
McRoberts BV, The Hague, Netherlands
Public Library of Science, UNITED KINGDOM
Author notes
Competing Interests: McRoberts is the manufacturer of the DynaPort. JE is employee of McRoberts. CB has
done consultation work for Philipps Healthcare, Bosch Healthcare, Eli Lilly and Gait-up;
he has received speaker honoraria from Amgen, Pfizer and Nutricia. LS is working as
the Chief Technical Officer for Rölke Pharma. JMH reports having submitted a patent
for assessment of mobility using wearable sensors in 400 Parkinson’s disease; the
intellectual property rights 401 are held by the Tel Aviv Medical Center. GC has received
consulting and speaking fees from Novartis, Sanofi Genzyme, Genzyme Corporation, Merck
KGgA, Merck Serono SpA, Celgene Group, F. Hoffman-La Roche, Almirall SpA, Janssen.
MFG is a full-time employee of Teva Pharmaceuticals. RRM is a full-time employee of
The Novartis Institutes for BioMedical Research. All other authors declare that they
have no competing interests.
¶ Membership of the Mobilise-D consortium is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PONE-D-22-14638
DOI: 10.1371/journal.pone.0269615
PMC ID: 9536536
PubMed ID: 36201476
SO-VID: b83fa5bd-6cc1-4400-bb8b-5b2e33a1cd70
Copyright © © 2022 Mikolaizak et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/501100010767, Innovative Medicines Initiative;
Award ID: 820820
This work was supported by the Mobilise-D project that has received funding from the
Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No.
820820. This JU receives support from the European Union's Horizon 2020 research and
innovation program and the European Federation of Pharmaceutical Industries and Associations
(EFPIA). The funding bodies do not have ultimate authority over any activities (study
design, collection, management, analysis, interpretation of data, writing of reports
and decision to submit for publication. A draft protocol for the clinical validation
was provided as part of the grant/funding application. Content in this publication
reflects the authors’ view and neither IMI nor the European Union, EFPIA, or any Associated
Partners are responsible for any use that may be made of the information contained
herein. ISGlobal acknowledges support from the Spanish Ministry of Science, Innovation
and Universities through the “Centro de Excelencia Severo Ochoa 2019-2023” Program
(CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA
Program. Heleen Demeyer is a post-doctoral fellow of the FWO Flanders. Heiko Gaßner
is supported by the Fraunhofer Internal Programs under Grant No. Attract 044-602140
and 044-602150
Subject:
Study Protocol
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Chronic Obstructive Pulmonary Disease
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Biological Locomotion
Subject:
Walking
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Biological Locomotion
Subject:
Gait Analysis
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Neurodegenerative Diseases
Subject:
Movement Disorders
Subject:
Parkinson Disease
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases
Subject:
Movement Disorders
Subject:
Parkinson Disease
Subject:
Computer and Information Sciences
Subject:
Data Management
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Demyelinating Disorders
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Demyelinating Disorders
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Neurodegenerative Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Data
