EdgeSVDNet: 5G-Enabled Detection and Classification of Vision-Threatening Diabetic Retinopathy in Retinal Fundus Images

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Abstract

The rise of vision-threatening diabetic retinopathy (VTDR) underscores the imperative for advanced and efficient early detection mechanisms. With the integration of the Internet of Things (IoT) and 5G technologies, there is transformative potential for VTDR diagnosis, facilitating real-time processing of the burgeoning volume of fundus images (FIs). Combined with artificial intelligence (AI), this offers a robust platform for managing vast healthcare datasets and achieving unparalleled disease detection precision. Our study introduces a novel AI-driven VTDR detection framework that integrates multiple models through majority voting. This comprehensive approach encompasses pre-processing, data augmentation, feature extraction using a hybrid convolutional neural network-singular value decomposition (CNN-SVD) model, and classification through an enhanced SVM-RBF combined with a decision tree (DT) and K-nearest neighbor (KNN). Validated on the IDRiD dataset, our model boasts an accuracy of 99.89%, a sensitivity of 84.40%, and a specificity of 100%, marking a significant improvement over the traditional method. The convergence of the IoT, 5G, and AI technologies herald a transformative era in healthcare, ensuring timely and accurate VTDR diagnoses, especially in geographically underserved regions.

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High-performance medicine: the convergence of human and artificial intelligence

Eric Topol (2019)

The use of artificial intelligence, and the deep-learning subtype in particular, has been enabled by the use of labeled big data, along with markedly enhanced computing power and cloud storage, across all sectors. In medicine, this is beginning to have an impact at three levels: for clinicians, predominantly via rapid, accurate image interpretation; for health systems, by improving workflow and the potential for reducing medical errors; and for patients, by enabling them to process their own data to promote health. The current limitations, including bias, privacy and security, and lack of transparency, along with the future directions of these applications will be discussed in this article. Over time, marked improvements in accuracy, productivity, and workflow will likely be actualized, but whether that will be used to improve the patient-doctor relationship or facilitate its erosion remains to be seen.

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Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning

Daniel Kermany, Michael Goldbaum, Wenjia Cai … (2018)

The implementation of clinical-decision support algorithms for medical imaging faces challenges with reliability and interpretability. Here, we establish a diagnostic tool based on a deep-learning framework for the screening of patients with common treatable blinding retinal diseases. Our framework utilizes transfer learning, which trains a neural network with a fraction of the data of conventional approaches. Applying this approach to a dataset of optical coherence tomography images, we demonstrate performance comparable to that of human experts in classifying age-related macular degeneration and diabetic macular edema. We also provide a more transparent and interpretable diagnosis by highlighting the regions recognized by the neural network. We further demonstrate the general applicability of our AI system for diagnosis of pediatric pneumonia using chest X-ray images. This tool may ultimately aid in expediting the diagnosis and referral of these treatable conditions, thereby facilitating earlier treatment, resulting in improved clinical outcomes. VIDEO ABSTRACT.

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Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

Todd Hollon, Balaji Pandian, Arjun R Adapa … (2020)

Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery 1 . The existing workflow for intraoperative diagnosis based on hematoxylin and eosin-staining of processed tissue is time-, resource-, and labor-intensive 2,3 . Moreover, interpretation of intraoperative histologic images is dependent on a contracting, unevenly distributed pathology workforce 4 . Here, we report a parallel workflow that combines stimulated Raman histology (SRH) 5–7 , a label-free optical imaging method, and deep convolutional neural networks (CNN) to predict diagnosis at the bedside in near real-time in an automated fashion. Specifically, our CNN, trained on over 2.5 million SRH images, predicts brain tumor diagnosis in the operating room in under 150 seconds, an order of magnitude faster than conventional techniques (e.g., 20–30 minutes) 2 . In a multicenter, prospective clinical trial (n = 278) we demonstrated that CNN-based diagnosis of SRH images was non-inferior to pathologist-based interpretation of conventional histologic images (overall accuracy, 94.6% vs. 93.9%). Our CNN learned a hierarchy of recognizable histologic feature representations to classify the major histopathologic classes of brain tumors. Additionally, we implemented a semantic segmentation method to identify tumor infiltrated, diagnostic regions within SRH images. These results demonstrate how intraoperative cancer diagnosis can be streamlined, creating a complimentary pathway for tissue diagnosis that is independent of a traditional pathology laboratory.