Long non-coding RNAs: insights into functions.

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Abstract

In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.

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Journal

Journal ID (iso-abbrev): Nat Rev Genet

Title: Nature reviews. Genetics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1471-0064

ISSN (Print): 1471-0056

Publication date (Electronic): Mar 2009

Volume: 10

Issue: 3

Affiliations

[1 ] Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

Article

Publisher Item ID: nrg2521

DOI: 10.1038/nrg2521

PubMed ID: 19188922

SO-VID: b765563f-dfce-4ada-88a3-cc53a27dbc74

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