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      Patterns and trends in eczema management in UK primary care (2009–2018): A population‐based cohort study

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          Abstract

          Background

          Despite the high disease burden of eczema, a contemporary overview of the patterns and trends in primary care healthcare utilization and treatment is lacking.

          Objective

          To quantify primary care consultations, specialist referrals, prescribing, and treatment escalation, in children and adults with eczema in England.

          Methods

          A large primary care research database was used to examine healthcare and treatment utilization in people with active eczema ( n = 411,931). Management trends and variations by age, sex, socioeconomic status, and ethnicity were described from 2009 to 2018 inclusive.

          Results

          Primary care consultation rates increased from 87.8 (95% confidence interval [95% CI] 87.3–88.3) to 112.0 (95% CI 111.5–112.6) per 100 person‐years over 2009 to 2018. Specialist referral rates also increased from 3.8 (95% CI 3.7–3.9) to 5.0 (95% CI 4.9–5.1) per 100 person‐years over the same period. Consultation rates were highest in infants. Specialist referrals were greatest in the over 50s and lowest in people of lower socioeconomic status, despite a higher rate of primary care consultations. There were small changes in prescribing over time; emollients increased (prescribed to 48.5% of people with active eczema in 2009 compared to 51.4% in 2018) and topical corticosteroids decreased (57.3%–52.0%). Prescribing disparities were observed, including less prescribing of potent and very potent topical corticosteroids in non‐white ethnicities and people of lower socioeconomic status. Treatment escalation was more common with increasing age and in children of non‐white ethnicity.

          Conclusion and clinical relevance

          The management of eczema varies by sociodemographic status in England, with lower rates of specialist referral in people from more‐deprived backgrounds. There are different patterns of healthcare utilization, treatment, and treatment escalation in people of non‐white ethnicity and of more‐deprived backgrounds.

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          Most cited references45

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          The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement

          Routinely collected health data, obtained for administrative and clinical purposes without specific a priori research goals, are increasingly used for research. The rapid evolution and availability of these data have revealed issues not addressed by existing reporting guidelines, such as Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). The REporting of studies Conducted using Observational Routinely collected health Data (RECORD) statement was created to fill these gaps. RECORD was created as an extension to the STROBE statement to address reporting items specific to observational studies using routinely collected health data. RECORD consists of a checklist of 13 items related to the title, abstract, introduction, methods, results, and discussion section of articles, and other information required for inclusion in such research reports. This document contains the checklist and explanatory and elaboration information to enhance the use of the checklist. Examples of good reporting for each RECORD checklist item are also included herein. This document, as well as the accompanying website and message board (http://www.record-statement.org), will enhance the implementation and understanding of RECORD. Through implementation of RECORD, authors, journals editors, and peer reviewers can encourage transparency of research reporting.
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            THE INVERSE CARE LAW

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              The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries

              The contribution of psychological disorders to the burden of skin disease has been poorly explored, and this is a large-scale study to ascertain the association between depression, anxiety, and suicidal ideation with various dermatological diagnoses. This international multicenter observational cross-sectional study was conducted in 13 European countries. In each dermatology clinic, 250 consecutive adult out-patients were recruited to complete a questionnaire, reporting socio-demographic information, negative life events, and suicidal ideation; depression and anxiety were assessed with the Hospital Anxiety and Depression Scale. A clinical examination was performed. A control group was recruited among hospital employees. There were 4,994 participants––3,635 patients and 1,359 controls. Clinical depression was present in 10.1% patients (controls 4.3%, odds ratio (OR) 2.40 (1.67–3.47)). Clinical anxiety was present in 17.2% (controls 11.1%, OR 2.18 (1.68–2.82)). Suicidal ideation was reported by 12.7% of all patients (controls 8.3%, OR 1.94 (1.33–2.82)). For individual diagnoses, only patients with psoriasis had significant association with suicidal ideation. The association with depression and anxiety was highest for patients with psoriasis, atopic dermatitis, hand eczema, and leg ulcers. These results identify a major additional burden of skin disease and have important clinical implications.
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                Author and article information

                Contributors
                carsten.flohr@kcl.ac.uk
                Journal
                Clin Exp Allergy
                Clin Exp Allergy
                10.1111/(ISSN)1365-2222
                CEA
                Clinical and Experimental Allergy
                John Wiley and Sons Inc. (Hoboken )
                0954-7894
                1365-2222
                23 November 2020
                March 2021
                : 51
                : 3 ( doiID: 10.1111/cea.v51.3 )
                : 483-494
                Affiliations
                [ 1 ] Nuffield Department of Primary Care health Sciences University of Oxford Oxford UK
                [ 2 ] Royal College of General Practitioners, Research and Surveillance Centre London UK
                [ 3 ] Unit for Population‐Based Dermatology Research St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust and King's College London London UK
                [ 4 ] Momentum Data Pendragon House St. Albans UK
                [ 5 ] Pfizer Ltd Tadworth UK
                Author notes
                [*] [* ] Correspondence

                Carsten Flohr, Unit for Population‐Based Dermatology Research, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust and King's College London WC2R 2LS, UK.

                Email: carsten.flohr@ 123456kcl.ac.uk

                Author information
                https://orcid.org/0000-0003-4884-6286
                Article
                CEA13783
                10.1111/cea.13783
                7984383
                33176023
                b70668c8-de5f-4012-becb-73fe0fc083dd
                © 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 07 October 2020
                : 10 July 2020
                : 28 October 2020
                Page count
                Figures: 4, Tables: 3, Pages: 12, Words: 8459
                Funding
                Funded by: National Institute for Health Research , open-funder-registry 10.13039/501100000272;
                Award ID: CDF‐2014‐07‐037
                Funded by: Pfizer Ltd
                Categories
                Original Article
                ORIGINAL ARTICLES
                Epidemiology of Allergic Disease
                Custom metadata
                2.0
                March 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.0 mode:remove_FC converted:22.03.2021

                Immunology
                atopic dermatitis,atopic eczema,dermatology,eczema,epidemiology,primary care,treatment
                Immunology
                atopic dermatitis, atopic eczema, dermatology, eczema, epidemiology, primary care, treatment

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