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      Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

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          Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

          This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
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            Is Open Access

            Nano based drug delivery systems: recent developments and future prospects

            Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.
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              Analysis of nanoparticle delivery to tumours

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                Author and article information

                Contributors
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                Journal
                ACS Applied Bio Materials
                ACS Appl. Bio Mater.
                American Chemical Society (ACS)
                2576-6422
                2576-6422
                March 21 2022
                February 28 2022
                March 21 2022
                : 5
                : 3
                : 971-1012
                Affiliations
                [1 ]Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
                [2 ]Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana 71270, United States
                [3 ]Interdisciplinary Graduate School of Engineering Science, Kyushu University, Fukuoka 816-8580, Japan
                [4 ]Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka 1349, Bangladesh
                [5 ]Department of Materials Science and Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh
                [6 ]Department of Biotechnology and Genetic Engineering, University of Development Alternative, Dhaka 1209, Bangladesh
                [7 ]Department of Chemical Engineering, University of Rhode Island, South Kingston, Rhode Island 02881, United States
                Article
                10.1021/acsabm.2c00002
                35226465
                b6ec1bcc-8276-487c-9aac-25413814e51f
                © 2022

                https://doi.org/10.15223/policy-029

                https://doi.org/10.15223/policy-037

                https://doi.org/10.15223/policy-045

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