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Abstract
The dopamine D4 receptor (DRD4) is a candidate gene in the search for a genetic etiology
of schizophrenia and for pharmacogenetic factors in the response to antipsychotic
treatment. Previous work has not found linkage or association of a polymorphism in
exon 3 of this gene with diagnosis of schizophrenia or response to clozapine. In this
study we examined this association in Israeli schizophrenic subjects treated with
clozapine, compared to ethnically matched controls. Another polymorphism of this gene,
in exon 1, was also studied. Both polymorphisms showed no association with schizophrenia
or treatment response. A significant difference in allelic distribution of DRD/ exon
3 polymorphism was found between Ashkenazi and non-Ashkenazi control subjects.