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      Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug-Drug Interaction Potentials.

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          Abstract

          To build a physiologically based pharmacokinetic (PBPK) model for fimasartan, amlodipine, and hydrochlorothiazide, and to investigate the drug-drug interaction (DDI) potentials.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Pharm Res
          Title: Pharmaceutical research
          Publisher: Springer Science and Business Media LLC
          ISSN (Electronic): 1573-904X
          ISSN (Print): 0724-8741
          Publication date (Electronic): Oct 15 2018
          Volume: 35
          Issue: 12
          Affiliations
          [1 ] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
          [2 ] Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Republic of Korea.
          [3 ] College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.
          [4 ] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. ksyu@snu.ac.kr.
          Article
          Publisher Item ID: 10.1007/s11095-018-2511-5
          DOI: 10.1007/s11095-018-2511-5
          PubMed ID: 30324316
          SO-VID: b5b091d8-420c-4750-a3aa-b5fe0303a646
          History

          Keywords: amlodipine,drug-drug interaction,fimasartan,hydrochlorothiazide,physiologically based pharmacokinetics
          Data availability:
          Keywords: amlodipine, drug-drug interaction, fimasartan, hydrochlorothiazide, physiologically based pharmacokinetics

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