Synergistic effect of HA and BMP-2 mimicking peptide on the bioactivity of HA/PMMA bone cement.

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Abstract

HA and bone morphogenetic protein-2 (BMP-2) possess superior osteoinductive and osteoconductive activities in the repair of bone defects. In this study, a BMP-2 mimicking oligopeptide (serine-serine-valine-proline-threonine, SSVPT) was introduced to the surface of nano-sized HA as the reinforcement phase of a poly(methyl methacrylate) (PMMA) cement, and the synergistic action of HA and oligopeptide on the bioactivity of HA/PMMA bone cement was investigated. Incorporated with 3-trimethoxysilyl propyl methacrylate (MPS)-modified HA, the compressive strength, flexural strength, and flexural modulus of HA/PMMA complied with the international standardization organization 5833 standard. Adherence measurement demonstrated that the introduction of HA and SSVPT could promote the adhesion and proliferation of human fetal osteoblast (hFOB) on the surface of HA/PMMA cement. The increased alkaline phosphatase (ALP) activity indicated that HA/PMMA could promote osteogenic differentiation of hFOB. All of the results illuminated that the HA/PMMA cement could be used as a bioactive material for regeneration and reconstruction of load-bearing bone.

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Author and article information

Journal

Journal ID (iso-abbrev): Colloids Surf B Biointerfaces

Title: Colloids and surfaces. B, Biointerfaces

Publisher: Elsevier BV

ISSN (Electronic): 1873-4367

ISSN (Print): 0927-7765

Publication date (Electronic): Jul 01 2015

Volume: 131

Affiliations

[1 ] Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China.

[2 ] Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

[3 ] Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: quancy2010@163.com.

[4 ] Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: zhchao9@mail.sysu.edu.cn.

Article

Publisher Item ID: S0927-7765(15)00250-7

DOI: 10.1016/j.colsurfb.2015.04.032

PubMed ID: 25948316

SO-VID: b4fc5d41-c182-4239-9595-d8acba4a6c86

History

Keywords: Nano-hydroxyapatite,Poly(methyl methacrylate),Synergistic action,BMP-2 mimicking peptide,Bioactivity

Data availability:

Keywords: Nano-hydroxyapatite, Poly(methyl methacrylate), Synergistic action, BMP-2 mimicking peptide, Bioactivity

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