Proliferation of HIV-1 reservoir cells: The delusion of infinite growth

Abstract

Kufera et al. demonstrate that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to be at least partially refractory to TCR stimulation.

Abstract

Proliferation of HIV-1–infected cells contributes to viral persistence despite antiretroviral therapy. A new study by Kufera et al. ( https://doi.org/10.1084/jem.20231511) demonstrates that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to be at least partially refractory to TCR stimulation, restricting their ability to proliferate in response to antigenic challenge.