Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden: A Randomized Clinical Trial.

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Abstract

Observational studies indicate that lower blood pressure (BP) increases risk for cognitive decline in elderly individuals. Older persons are at risk for impaired cerebral autoregulation; lowering their BP may compromise cerebral blood flow and cognitive function.

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Journal

Journal ID (iso-abbrev): JAMA Intern Med

Title: JAMA internal medicine

Publisher: American Medical Association (AMA)

ISSN (Electronic): 2168-6114

ISSN (Print): 2168-6106

Publication date (Electronic): Oct 2015

Volume: 175

Issue: 10

Affiliations

[1 ] Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.

[2 ] Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.

[3 ] Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

[4 ] Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands4Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

[5 ] Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands6Section of Health, Medical and Neuropsychology, Department of Psychology, Leiden University, Leiden, the Netherlands.

[6 ] Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

[7 ] Leyden Academy on Vitality and Aging, Leiden University Medical Center, Leiden, the Netherlands8Center for Healthy Aging, Department of Public Health, University of Copenhagen, Cophenhagen, Denmark.

[8 ] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

[9 ] Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands9Department of Psychiatry, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.

Article

Publisher Item ID: 2429535

DOI: 10.1001/jamainternmed.2015.4103

PubMed ID: 26301603

SO-VID: b4c0b875-89e2-4171-994b-79e71afceda9

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