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      Ação do laser terapêutico e do ultrassom na regeneração nervosa periférica Translated title: Action of therapeutic laser and ultrasound in peripheral nerve regeneration

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          Abstract

          OBJETIVO: Avaliar a ação precoce do laser terapêutico e do ultrassom no processo de regeneração de uma lesão experimental em ratos. MÉTODO: Utilizou-se 24 ratos. Dezoito foram submetidos ao procedimento cirúrgico de lesão do nervo ciático por compressão, através de uma pinça hemostática acima da fossa poplítea. Os animais foram divididos em três grupos com seis animais em cada. Grupo controle normal. GI: controle lesado sem intervenção terapêutica. GII: intervenção terapêutica do laser ArGaAl. GIII: intervenção terapêutica do ultrassom Pulsado. Iniciamos as intervenções terapêuticas 24 horas após a lesão, com aplicações diárias, por um período de quatorze dias consecutivos. RESULTADOS: Ao avaliar a perimetria dos músculos da coxa direita obteve-se os seguintes valores médios de diminuição (mm), para cada grupo GI: 0,45; GII: 0,42; GIII: 0,40. Quanto ao tempo de deslocamento tanto o GII e GIII apresentaram diferença significativa, quando comparados ao GI. Na avaliação final do IFC o GII sobressaiu ao GIII. Quanto a cicatrização observou-se grande melhora no GII e GIII. CONCLUSÃO: Os resultados evidenciaram que a recuperação nervosa foi maior com a aplicação do laser. Nível de evidência II, Estudos terapêuticos - Investigação dos resultados do tratamento

          Translated abstract

          OBJECTIVE: To assess the efficacy of early therapeutic laser and ultrasound in the regeneration process of an injury in rats. METHODS: We used 24 rats. Eighteen underwent surgery for sciatic nerve compression by a hemostat above the popliteal fossa. The animals were divided into three groups of six animals each. Normal control group. GI: Injured control without therapeutic intervention. GII: laser ArGaAl therapeutic intervention. GIII: therapeutic intervention of Pulsed Ultrasound. We begin therapeutic interventions 24 hours after injury, with daily applications for a period of fourteen consecutive days. RESULTS: In assessing the girth of the muscles of the right they, the following average decrease (in mm) for each GI: 0.45, GII: 0.42, GIII: 0.40 In relation to travel time, both GII and GIII presented significant difference when compared to GI. In the final evaluation of the IFC, GII excelled in the GIII. As for the healing observed, a major great improvement was observed in GII and GIII. CONCLUSION: The results showed that nerve recovery was higher with the laser application. Level of evidence II, Therapeutic Studies - Investigation of the results of treatment.

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          Most cited references20

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          An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks.

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            A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance.

            G Lundborg (2000)
            In spite of an enormous amount of new experimental laboratory data based on evolving neuroscientific concepts during the last 25 years peripheral nerve injuries still belong to the most challenging and difficult surgical reconstructive problems. Our understanding of biological mechanisms regulating posttraumatic nerve regeneration has increased substantially with respect to the role of neurotrophic and neurite-outgrowth promoting substances, but new molecular biological knowledge has so far gained very limited clinical applications. Techniques for clinical approximation of severed nerve ends have reached an optimal technical refinement and new concepts are needed to further increase the results from nerve repair. For bridging gaps in nerve continuity little has changed during the last 25 years. However, evolving principles for immunosuppression may open new perspectives regarding the use of nerve allografts, and various types of tissue engineering combined by bioartificial conduits may also be important. Posttraumatic functional reorganizations occurring in brain cortex are key phenomena explaining much of the inferior functional outcome following nerve repair, and increased knowledge regarding factors involved in brain plasticity may help to further improve the results. Implantation of microchips in the nervous system may provide a new interface between biology and technology and developing gene technology may introduce new possibilities in the manipulation of nerve degeneration and regeneration.
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              Techniques for nerve grafting.

              H Millesi (2000)
              The nerve graft can be completed using many different techniques. This article elaborates the general principles and many details that can be approached in different ways when dealing with nerve grafting. A review of the reasons for the poor performance of early nerve grafts, as well as the origins of nerve grafts, is included. This article discusses the technical aspects of nerve grafting including free nerve grafting and timing and exposure.
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                Author and article information

                Journal
                aob
                Acta Ortopédica Brasileira
                Acta ortop. bras.
                ATHA EDITORA (São Paulo, SP, Brazil )
                1413-7852
                1809-4406
                2012
                : 20
                : 2
                : 98-103
                Affiliations
                [01] orgnameCentro Universitário do Planalto de Araxá Brasil
                [02] Vila Real orgnameUniversity of Trás-os-Montes and Alto Douro orgdiv1Department of Sport Science Portugal
                [03] Ribeirão Preto SP orgnameUSP orgdiv1FMRP orgdiv2Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor Brasil
                [04] Franca SP orgnameUniversidade de Franca Brasil
                Article
                S1413-78522012000200008 S1413-7852(12)02000208
                b460d1d1-49b7-443b-9c1d-9e31a3f6a097

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 22 July 2011
                : 16 August 2011
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 20, Pages: 6
                Product

                SciELO Brazil

                Categories
                Artigo Original

                Laser therapy, low-level,Ultrasonic therapy,Sciatic nerve,Nerve crush,Terapia a laser de baixa intensidade,Terapia por ultrassom,Nerve regeneration,Regeneração nervosa,Compressão nervosa,Nervo ciático

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