Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

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Abstract

The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic “smart” delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.

Most cited references 42

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Fiji: an open-source platform for biological-image analysis.

Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise … (2020)

Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis. Fiji uses modern software engineering practices to combine powerful software libraries with a broad range of scripting languages to enable rapid prototyping of image-processing algorithms. Fiji facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system. We propose Fiji as a platform for productive collaboration between computer science and biology research communities.

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Structural and functional features of central nervous system lymphatics

Antoine Louveau, Igor Smirnov, Timothy Keyes … (2015)

One of the characteristics of the CNS is the lack of a classical lymphatic drainage system. Although it is now accepted that the CNS undergoes constant immune surveillance that takes place within the meningeal compartment 1–3 , the mechanisms governing the entrance and exit of immune cells from the CNS remain poorly understood 4–6 . In searching for T cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the CSF, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the CNS. The discovery of the CNS lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and shed new light on the etiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

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The Microenvironmental Landscape of Brain Tumors

Daniela Quail, Johanna A. Joyce (2017)

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.

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Author and article information

Contributors

Oxana Semyachkina-Glushkovskaya: (View ORCID Profile)

Journal

Title: Nanophotonics

Publisher: Walter de Gruyter GmbH

ISSN (Electronic): 2192-8614

Publication date Created: September 20 2021

Publication date Created: June 18 2021

Publication date Created: September 02 2021

Publication date (Print): September 20 2021

Publication date (Electronic): July 09 2021

Publication date (Print): September 02 2021

Volume: 10

Issue: 12

Pages: 3215-3227

Affiliations

[1 ]Humboldt University , Newtonstrasse 15 , 12489 Berlin , Germany

[2 ]Saratov State University , Astrakhanskaya 82 , 410012 Saratov , Russia

[3 ]Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences , Prospekt Entuziastov 13 , 410049 Saratov , Russia

[4 ]Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences , Miklukho-Maklaya 16/10 , 117997 Moscow , Russia

[5 ]Optoelectronics and Biomedical Photonics Group, AIPT, Aston University , Birmingham , B4 7ET , UK

[6 ]Charité-Universitätsmedizin Berlin, Sleep Medicine Center , Charitéplatz 1 , 10117 Berlin , Germany

[7 ]Potsdam Institute for Climate Impact Research , Telegrafenberg A31 , 14473 Potsdam , Germany

Article

DOI: 10.1515/nanoph-2021-0212

SO-VID: b3c74229-9311-482a-bb7a-8b71ddce9dbc

License:

http://creativecommons.org/licenses/by/4.0

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