Isolated Ocular Mpox without Skin Lesions, United States

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Abstract

We report a case of a 53-year-old HIV-negative patient in San Francisco, California, USA, with no classic mpox prodromal symptoms or skin lesions who experienced fulminant, vision-threatening scleritis, keratitis, and uveitis. Deep sequence analysis identified monkeypox virus RNA in the aqueous humor. We confirmed the virus on the cornea and sclera by PCR.

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Most cited references 7

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Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022

John P. Thornhill, Sapha Barkati, Sharon Walmsley … (2022)

Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined.

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Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022

Jesús Iñigo Martínez, Elisa Gil Montalbán, Susana Jiménez Bueno … (2022)

Up to 22 June 2022, 508 confirmed cases of monkeypox (MPX) have been reported in the Madrid region of Spain, 99% are men (n = 503) with a median age of 35 years (range: 18–67). In this ongoing outbreak, 427 cases (84.1%) reported condomless sex or sex with multiple partners within the 21 days before onset of symptoms, who were predominantly men who have sex with men (MSM) (n = 397; 93%). Both the location of the rash, mainly in the anogenital and perineal area, as well as the presence of inguinal lymphadenopathy suggest that close physical contact during sexual activity played a key role in transmission. Several cases reported being at a sauna in the city of Madrid (n = 34) or a mass event held on the Spanish island of Gran Canaria (n = 27), activities which may represent a conducive environment for MPX virus spread, with many private parties also playing an important role. Because of the rapid implementation of MPX surveillance in Madrid, one of the largest outbreaks reported outside Africa was identified. To minimise transmission, we continue to actively work with LGBTIQ+ groups and associations, with the aim of raising awareness among people at risk and encouraging them to adopt preventive measures.

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Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding

Daniele Lapa, Fabrizio Carletti, Valentina Mazzotta … (2022)

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Author and article information

Journal

Journal ID (nlm-ta): Emerg Infect Dis

Journal ID (iso-abbrev): Emerg Infect Dis

Journal ID (publisher-id): EID

Title: Emerging Infectious Diseases

Publisher: Centers for Disease Control and Prevention

ISSN (Print): 1080-6040

ISSN (Electronic): 1080-6059

Publication date (Print): June 2023

Volume: 29

Issue: 6

Pages: 1285-1288

Affiliations

[1]University of California, San Francisco, California, USA (M.T. Nguyen, A. Mentreddy, J. Schallhorn, M. Chan, S. Aung, S.B. Doernberg, J. Babik, K. Miles, K. Yang, E. Lydon, D.J. Minter, J. Gonzales, J. Shantha, T. Doan, G.D. Seitzman);

[2]Francis I. Proctor Foundation, San Francisco (M.T. Nguyen, A. Mentreddy, M. Chan, J. Gonzales, J. Shantha, T. Doan, G.D. Seitzman)

Author notes

Address for correspondence: Gerami D. Seitzman, University of California San Francisco—Ophthalmology, 490 Illinois St, San Francisco, CA 94158, USA; email: gerami.seitzman@ 123456ucsf.edu

Article

Publisher ID: 23-0032

DOI: 10.3201/eid2906.230032

PMC ID: 10202873

PubMed ID: 37130504

SO-VID: b3ad6ca2-ee13-4764-a0b6-73c64b2e9b23

License:

Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

Isolated Ocular Mpox without Skin Lesions, United States

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Abstract

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Monkeypox

Most cited references 7

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022

Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022

Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding

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