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Abstract
Abundant evidence leaves no doubt that reactive oxygen species (ROS) are not only
inevitable by-products of oxygen metabolism but also play a role in cellular signaling.
ROS are produced by a family of NADPH oxidases for signaling purposes and mediate
or augment the effects of insulin, growth factors, cytokines and G-protein-coupled
receptors. Disturbances of ROS signaling leading to overproduction of these intermediates
inflict oxidative damage of cell components in the course of various diseases. Restoration
of proper ROS signaling, especially inhibition of cellular sources of ROS, may thus
provide new ways of therapy.