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      Valorisation of crude glycerol to value-added products: Perspectives of process technology, economics and environmental issues

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          Highlights

          • Glycerol can be converted to value-added products using different catalytic processes.

          • Optimum process technology for glycerol conversion depends on specific reaction conditions.

          • Sustainability of the products developed depend upon economic output and chemical conversion is preferred.

          • Environmental benefits encourage biochemical routes over chemical routes.

          Abstract

          The enormous production of glycerol, a waste stream from biodiesel industries, as a low-value product has been causing a threat to both the environment and the economy. Therefore, it needs to be transformed effectively and efficiently into valued products for contributing positively towards the biodiesel economy. It can either be converted directly into competent chemicals or can be used as a feedstock/precursor for deriving valuable derivatives. In this review article, a technical evaluation has been stirred up, various factors and technologies used for producing value-added products from crude glycerol, Environmental and economic aspects of different conversion routes, cost factors and challenges of integration of the different routes for biorefinery have been reviewed and elaborated. There are tremendous environmental benefits in the conversion of crude glycerol via the biochemical route, the product and residue become eco-friendly. However, chemical conversions are faster processes, and economically viable if environmental aspects are partially ignored.

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          Improved utilisation of renewable resources: New important derivatives of glycerol

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            A versatile toolkit for high throughput functional genomics with Trichoderma reesei

            Background The ascomycete fungus, Trichoderma reesei (anamorph of Hypocrea jecorina), represents a biotechnological workhorse and is currently one of the most proficient cellulase producers. While strain improvement was traditionally accomplished by random mutagenesis, a detailed understanding of cellulase regulation can only be gained using recombinant technologies. Results Aiming at high efficiency and high throughput methods, we present here a construction kit for gene knock out in T. reesei. We provide a primer database for gene deletion using the pyr4, amdS and hph selection markers. For high throughput generation of gene knock outs, we constructed vectors using yeast mediated recombination and then transformed a T. reesei strain deficient in non-homologous end joining (NHEJ) by spore electroporation. This NHEJ-defect was subsequently removed by crossing of mutants with a sexually competent strain derived from the parental strain, QM9414. Conclusions Using this strategy and the materials provided, high throughput gene deletion in T. reesei becomes feasible. Moreover, with the application of sexual development, the NHEJ-defect can be removed efficiently and without the need for additional selection markers. The same advantages apply for the construction of multiple mutants by crossing of strains with different gene deletions, which is now possible with considerably less hands-on time and minimal screening effort compared to a transformation approach. Consequently this toolkit can considerably boost research towards efficient exploitation of the resources of T. reesei for cellulase expression and hence second generation biofuel production.
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              Functionalised heterogeneous catalysts for sustainable biomass valorisation

              Functionalised heterogeneous catalysts show great potentials for efficient valorisation of renewable biomass to value-added chemicals and high-energy density fuels. Efficient transformation of biomass to value-added chemicals and high-energy density fuels is pivotal for a more sustainable economy and carbon-neutral society. In this framework, developing potential cascade chemical processes using functionalised heterogeneous catalysts is essential because of their versatile roles towards viable biomass valorisation. Advances in materials science and catalysis have provided several innovative strategies for the design of new appealing catalytic materials with well-defined structures and special characteristics. Promising catalytic materials that have paved the way for exciting scientific breakthroughs in biomass upgrading are carbon materials, metal–organic frameworks, solid phase ionic liquids, and magnetic iron oxides. These fascinating catalysts offer unique possibilities to accommodate adequate amounts of acid–base and redox functional species, hence enabling various biomass conversion reactions in a one-pot way. This review therefore aims to provide a comprehensive account of the most significant advances in the development of functionalised heterogeneous catalysts for efficient biomass upgrading. In addition, this review highlights important progress ensued in tailoring the immobilisation of desirable functional groups on particular sites of the above-listed materials, while critically discussing the role of consequent properties on cascade reactions as well as on other vital processes within the bio-refinery. Current challenges and future opportunities towards a rational design of novel functionalised heterogeneous catalysts for sustainable biomass valorisation are also emphasized.
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                Author and article information

                Contributors
                Journal
                Biotechnol Rep (Amst)
                Biotechnol Rep (Amst)
                Biotechnology Reports
                Elsevier
                2215-017X
                12 June 2020
                September 2020
                12 June 2020
                : 27
                : e00487
                Affiliations
                [a ]Department of Chemical Engineering, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India
                [b ]Chemical Conversion Division, Sardar Swaran Singh National Institute of Bio-Energy (An Autonomous Institute of MNRE Government of India), Kapurthala, Punjab, India
                Author notes
                [* ]Corresponding author. anil.sarma16@ 123456gov.in
                Article
                S2215-017X(20)30130-2 e00487
                10.1016/j.btre.2020.e00487
                7334398
                b2259bab-37b3-4abe-974e-7effd70e0023
                © 2020 Published by Elsevier B.V.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 20 February 2020
                : 9 April 2020
                : 8 June 2020
                Categories
                Review Article

                crude glycerol,conversion route,value-added products,economic aspects,environmental benefits and limitations

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