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      Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl

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          Abstract

          Three new phytoecdysteroid compounds, named niuxixinsterone A ( 1), B ( 2) and C ( 3) with acetal functions in the side-chain were isolated from Achyranthes bidentata Bl. The structures were established as (20 R,22 R,24 S)-20- O,22- O-(5′-hydroxymethyl)-furfurylidene-2β,3β,14α,25-tetrahydroxy-5β-ergost-7-en-6-one ( 1), (20 R,22 R)-20- O,22- O-(5′-hydroxymethyl)-furfurylidene-2β,3β,25-trihydroxy-14β-methyl-18-nor-5β-cholesta-7,12-dien-6-one ( 2) and (20 R,22 R,25 R)-20- O,22- O-(5′-hydroxymethyl)-furfurylidene-2β, 3β,5β,14α,26-pentahydroxycholest-7-en-6-one ( 3) by means of spectroscopic evidence.

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          Inhibiting effects of Achyranthes bidentata polysaccharide and Lycium barbarum polysaccharide on nonenzyme glycation in D-galactose induced mouse aging model.

          Yan Feng, Peng Cui, Bin Deng … (2003)
          To investigate the inhibiting effects and mechanism of achyranthes bidentata polysaccharide (ABP) and lycium barbarum polysaccharide (LBP) on nonenzyme glycation in D-galactose induced mouse aging model. Serum AGE levels were determined by AGE-ELISA, MTT method was used to determine lymphocyte proliferation, IL-2 activity was determined by a bioassay method. Spontaneous motor activity was used to detect mouse's neuromuscular movement, latency of step-through method was used to examine learning and memory abilities of mouse, colormetric assay was used to determine hydroxyproline concentration in mouse skin, pyrogallol autoxidation method was used to determine superoxide dismutase (SOD) activity of erythrocytes. Decreased levels of serum AGE, hydroxyproline concentration in mouse skin and spontaneous motor activity in D-galactose mouse aging model were detected after treated with ABP or LBP, while lymphocyte proliferation and IL-2 activity, learning and memory abilities, SOD activity of erythrocytes, were enhanced. ABP and LBP could inhibit nonenzyme glycation in D-galactose induced mouse aging model in vivo and ABP has a better inhibiting effect than LBP.
          Article 0 comments Cited 27 times – based on 0 reviews     Review now
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            Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity on osteoclast formation.

            Jian-Xin Li, Toru Hareyama, Yasuhiro Tezuka … (2005)
            Bioassay-directed fractionation of a butanol-soluble fraction of methanol extract of the root of Achyranthes bidentata resulted in the isolation of 5 new oleanolic acid glycosides 1-5, namely, 18-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3beta-yl 3-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosiduronic acid methyl ester (1), achyranthoside C dimethyl ester (2), achyranthoside C butyl dimethyl ester (3), achyranthoside E dimethyl ester (4), and achyranthoside E butyl methyl ester (5), together with 10 known compounds. Their structures were established on the basis of spectroscopic interpretation and chemical methods. All the oleanolic acid glycosides inhibited the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha,25(OH)2D3 in a co-culture assay system.
            Article 0 comments Cited 17 times – based on 0 reviews     Review now
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              Ecdysteroids from Vitex species: distribution and compilation of their 13C-NMR spectral data.

              Arménio Barbosa, G Sena, Carlos E L Cunha … (2008)
              Iridoids and ecdysteroids are found in some genera of the family Verbenaceae. In such cases, they are used as chemotaxonomic markers for the difficult task of taxonomic identification by using morphological characteristics of plants belonging to this family. The present work describes the distribution of ecdysteroids in plants from the genus Vitex from a review of previous work on seventeen Vitex species. In addition, (13)C-NMR data of the main ecdysteroids found in this genus are described. This study attempted to summarize previous research on ecdysteroids distribution in Vitex species with the addition of (13)C-NMR analysis to further refine the characterization of these compounds in the Verbenaceae family.
              Article 0 comments Cited 11 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 18 July 2011
                Publication date Collection: July 2011
                Volume: 16
                Issue: 7
                Pages: 5989-5997
                Affiliations
                Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine), Ministry of Education, No. 24 HePing Road, XiangFang District, Harbin 150040, China
                Author notes
                [†]

                These authors contributed equally to this work.

                [* ] Author to whom correspondence should be addressed; Email: hxkuang@ 123456hotmail.com ; Tel.: +86-451-82193001; Fax: +86-451-82110803.
                Article
                Publisher ID: molecules-16-05989
                DOI: 10.3390/molecules16075989
                PMC ID: 6264565
                PubMed ID: 21769064
                SO-VID: b202e8ee-a203-4333-b606-134c7ef95fb3
                Copyright © © 2011 by the authors;
                License:

                licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 10 May 2011
                Date revision received : 13 July 2011
                Date accepted : 13 July 2011
                Categories
                Subject: Article

                Keywords: achyranthes bidentata bl.,phytoecdysteroid,niuxixinsterone
                Data availability:
                Keywords: achyranthes bidentata bl., phytoecdysteroid, niuxixinsterone

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