Incidences of noncompliance with COVID-19 prevention and control policies have occurred worldwide, increasing the risk to public safety and making epidemic control more difficult. We applied the approach–inhibition theory of power perception to investigate the underlying mechanisms and boundary conditions of the relationship between individuals' power perception and their prevention and control policy compliance. This study collected data from 303 participants in 45 counties (districts) spanning one province in China. Results show that individuals' sense of power was negatively related to their prevention and control policy compliance, with risk perception mediating and group policy control moderating this relationship. The findings provide a reference for assessing the effectiveness and relevance of government epidemic prevention and control. Implications for research and practice are discussed.