Concurrent use of Antiretroviral and African traditional medicines amongst people living with HIV/AIDS (PLWA) in the eThekwini Metropolitan area of KwaZulu Natal

Abstract

<div class="section"> <a class="named-anchor" id="d6966377e89"> <!-- named anchor --> </a> <h5 class="section-title" id="d6966377e90">Background</h5> <p id="d6966377e92">People living with HIV/AIDS (PLWA) often use African Traditional Medicines (ATM) either alone or in combination with Western medicines including Antiretrovirals (ARV). </p> </div><div class="section"> <a class="named-anchor" id="d6966377e94"> <!-- named anchor --> </a> <h5 class="section-title" id="d6966377e95">Objectives</h5> <p id="d6966377e97">To explore the prevalence of concurrent Antiretrovirals (ARV) and African Traditional medicines (ATM) use and determine the effects of any concurrent use on the CD4+ Lymphocyte count and Viral Load (VL) of PLWA in the eThekwini Metropolitan area. </p> </div><div class="section"> <a class="named-anchor" id="d6966377e99"> <!-- named anchor --> </a> <h5 class="section-title" id="d6966377e100">Methods</h5> <p id="d6966377e102">A descriptive and exploratory study was carried out on 360 patients. Information was gathered on patients socioeconomic characteristics, ATM usage, outcome measures of HIV disease progression (CD4+ Count, VL). The data was analysed using descriptive statistics, univariate and multivariate analyses. </p> </div><div class="section"> <a class="named-anchor" id="d6966377e104"> <!-- named anchor --> </a> <h5 class="section-title" id="d6966377e105">Results</h5> <p id="d6966377e107">4.98% (14/281) of the patients used ATM and ARV concurrently during the study period. Over 65% (185/281) reported ATM use before diagnosis with HIV whilst 77.6% (218/281) reported previous ATM use after their HIV diagnosis but before initiation with ARV. Place of residence (p=0.004), age (p&lt;0.001) and education level (P=0.041) were found to be significantly and positively correlated with ATM use. There were no statistically significant changes in mean plasma CD4+ Count and inconclusive effects on VL during the period of the study in the group taking ARV alone when compared with the group using ARV and ATM concomitantly. </p> </div><div class="section"> <a class="named-anchor" id="d6966377e109"> <!-- named anchor --> </a> <h5 class="section-title" id="d6966377e110">Conclusion</h5> <p id="d6966377e112">Concurrent ARV and ATM use is quite low (4.98%) when compared to ATM use before HIV diagnosis and after HIV diagnosis but before initiation with ARV. This may point to efficient pre-counselling efforts before ARV initiation by health care professionals. This study also demonstrated that there were no significant differences in the CD4+ and inconclusive effects on VL, between patients taking both ARV and ATM concomitantly and those using ARV alone. </p> </div>