Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

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Abstract

Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

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Imaging and drug delivery using theranostic nanoparticles.

Siti Janib, Ara S Moses, J. MacKay (2010)

Nanoparticle technologies are significantly impacting the development of both therapeutic and diagnostic agents. At the intersection between treatment and diagnosis, interest has grown in combining both paradigms into clinically effective formulations. This concept, recently coined as theranostics, is highly relevant to agents that target molecular biomarkers of disease and is expected to contribute to personalized medicine. Here we review state-of-the-art nanoparticles from a therapeutic and a diagnostic perspective and discuss challenges in bringing these fields together. Major classes of nanoparticles include, drug conjugates and complexes, dendrimers, vesicles, micelles, core-shell particles, microbubbles, and carbon nanotubes. Most of these formulations have been described as carriers of either drugs or contrast agents. To observe these formulations and their interactions with disease, a variety of contrast agents have been used, including optically active small molecules, metals and metal oxides, ultrasonic contrast agents, and radionuclides. The opportunity to rapidly assess and adjust treatment to the needs of the individual offers potential advantages that will spur the development of theranostic agents. Copyright © 2010 Elsevier B.V. All rights reserved.

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Author and article information

Journal

Journal ID (nlm-ta): Polymers (Basel)

Journal ID (iso-abbrev): Polymers (Basel)

Journal ID (publisher-id): polymers

Title: Polymers

Publisher: MDPI

ISSN (Electronic): 2073-4360

Publication date (Electronic): 06 March 2020

Publication date Collection: March 2020

Volume: 12

Issue: 3

Electronic Location Identifier: 598

Affiliations

[1 ]Department of Chemistry, College of Sciences, Taibah University, Al-Medina Al-Munawara 41477, Saudi Arabia; mhsehli@ 123456taibahu.edu.sa

[2 ]Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi 110025, India

[3 ]Cheminformatics Laboratory—Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba-Campus I, João Pessoa 58051-970, PB, Brazil; luciana.scotti@ 123456gmail.com (L.S.); mtscotti@ 123456gmail.com (M.T.S.)

[4 ]Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan 32023, Taiwan; shant7707@ 123456gmail.com (S.-T.T.); shung804@ 123456yahoo.com.tw (R.-S.Y.); mfhsieh@ 123456cycu.edu.tw (M.F.H.)

[5 ]Center for Minimally-Invasive Medical Devices and Technologies, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan 32023, Taiwan

[6 ]Department of Pharmacy, Kaohsiung Armed Forces General Hospital, No.2, Zhongzheng 1st Rd., Lingya Dist., Kaohsiung 80284, Taiwan

[7 ]Institute of Biomedical Engineering, National Chiao Tung University, 1001 University Rd., Hsinchu 300, Taiwan; george@ 123456nctu.edu.tw

Author notes

[* ]Correspondence: drimran.chiral@ 123456gmail.com or drimran_ali@ 123456yahoo.com

[†]

Co-Correspondence authors.

Author information

Imran Ali https://orcid.org/0000-0001-6511-8374

Luciana Scotti https://orcid.org/0000-0003-1866-4107

Marcus Tullius Scotti https://orcid.org/0000-0003-4863-8057

Shang-Ting Tsai https://orcid.org/0000-0001-5705-602X

Ming Fa Hsieh https://orcid.org/0000-0001-5254-1341

Jung-Chih Chen https://orcid.org/0000-0003-3958-6806

Article

Publisher ID: polymers-12-00598

DOI: 10.3390/polym12030598

PMC ID: 7182942

PubMed ID: 32155695

SO-VID: b14e20d3-78d3-4160-a25a-a69c4cd31aa7

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

History

Date received : 28 November 2019

Date accepted : 01 January 2020

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Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

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Most cited references 218

New Developments in Liposomal Drug Delivery.

Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules

Imaging and drug delivery using theranostic nanoparticles.

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