Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.

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Abstract

Association between ten single-nucleotide polymorphisms (SNPs) in the human ALOX12 and ALOX15 genes and variations in peak bone mineral density (BMD) in a large sample of Chinese nuclear families with female offspring using the quantitative transmission disequilibrium test (QTDT). Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.

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Journal

Journal ID (iso-abbrev): Osteoporos Int

Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

ISSN (Electronic): 1433-2965

ISSN (Print): 0937-941X

Publication date (Electronic): Jul 2012

Volume: 23

Issue: 7

Affiliations

[1 ] Metabolic Bone Disease and Genetics Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, China.

Article

DOI: 10.1007/s00198-011-1835-3

PubMed ID: 22089472

SO-VID: b14b857d-c9a9-4300-9aeb-d90e383a8d1d

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